{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed context‐dependent roles for MIR4492 in regulating critical cellular processes. In bladder cancer, MIR4492 functions as a tumor‐suppressive microRNA by targeting ROMO1, a protein involved in oxidative stress and cell proliferation. However, its activity is attenuated by the oncogenic long noncoding RNA LINC00319, which acts as a molecular sponge for MIR4492. The suppression of MIR4492 by LINC00319 results in elevated ROMO1 expression, thereby enhancing proliferation, migration, and invasiveness of bladder cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn an inflammatory context, MIR4492 is implicated in the pathogenesis of osteoarthritis. Exposure of osteoarthritis synovial fibroblasts to IL-17 activates the MEK/ERK signaling cascade, which in turn modulates MIR4492 levels. This activation of the MEK/ERK/MIR4492 axis leads to increased production of the proinflammatory cytokine IL-18, suggesting that MIR4492 plays a role in mediating inflammatory responses within joint tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTogether, these findings highlight the versatile functions of MIR4492 across diverse biological environments. In cancer, its negative regulation by LINC00319 disrupts its tumor-suppressive effects, thereby facilitating oncogenic progression, while in osteoarthritis, its involvement in the MEK/ERK signaling axis underscores its contribution to inflammatory cytokine production. These insights into MIR4492’s dual roles open avenues for targeted therapeutic strategies in both oncologic and inflammatory disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yu Yang, Fangyi Zhang, Hang Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29271"}], "href": "https://doi.org/10.1002/jcp.29271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31608995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31608995"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kun-Tsan Lee, Chih-Yang Lin, Shan-Chi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.205462"}], "href": "https://doi.org/10.18632/aging.205462"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38261743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38261743"}]}]}]}