{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent research aimed at identifying reliable biomarkers for major depressive disorder (MDD) has focused on profiling microRNA (miRNA) expression in peripheral blood mononuclear cells. In one study, a panel of miRNAs—including miRNA‑26b, miRNA‑1972, miRNA‑4485, miRNA‑4498, and miRNA‑4743—was found to be up‑regulated in MDD patients, with bioinformatic analyses suggesting that these miRNAs participate in pathways related to nervous system and brain functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough the study provided valuable insight into miRNA dysregulation in MDD, it did not report any data concerning MIR4495. As such, no functional role for MIR4495 was described or implicated in the context of MDD pathogenesis based on the available abstract."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while differential expression of select miRNAs in peripheral blood cells appears to be associated with mechanisms underlying MDD, the function of MIR4495 remains undetermined in this investigation. Future studies that include MIR4495 in their analyses will be required to elucidate its potential involvement in MDD and related neurobiological pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui-min Fan, Xin-yang Sun, Wei Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatr Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jpsychires.2014.08.007"}], "href": "https://doi.org/10.1016/j.jpsychires.2014.08.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25201637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25201637"}]}]}]}