{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have begun to elucidate the functions of miR‑4497 in distinct pathological settings. In laryngeal squamous cell carcinoma (LSCC), miR‑4497 appears to serve as a tumor suppressor by negatively regulating key oncogenic factors. One study demonstrated that miR‑4497 suppresses LSCC progression by downregulating gastrulation brain homeobox 2 (GBX2), while another investigation further implicated miR‑4497 in inhibiting cell migration and invasion through interactions with the long noncoding RNA FEZF1‑AS1. Collectively, these findings suggest that miR‑4497 plays a critical anticancer role in LSCC by modulating gene networks that control cell proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its functions in tumor suppression, aberrant expression of miR‑4497 has been observed in placental tissues associated with early recurrent miscarriage. Overexpression of miR‑4497 in placental villi may disrupt normal trophoblast function and placental development, thereby contributing to the pathogenesis of miscarriage. This emerging evidence indicates that miR‑4497 could serve as a novel mediator of placental dysfunction in early pregnancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xudong Chen, Litao Zhang, Shixiong Tang "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-4497 functions as a tumor suppressor in laryngeal squamous cell carcinoma via negatively modulation the GBX2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Auris Nasus Larynx (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.anl.2018.05.005"}], "href": "https://doi.org/10.1016/j.anl.2018.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29843929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29843929"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xudong Chen, Peng Cheng, Cihao Hu "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA FEZF1-AS1 accelerates the migration and invasion of laryngeal squamous cell carcinoma cells through miR-4497 targeting GBX2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Arch Otorhinolaryngol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00405-021-06636-5"}], "href": "https://doi.org/10.1007/s00405-021-06636-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33550476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33550476"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Huaiyun Tang, Linqing Pan, Yun Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of the Sp1 transcription factor by an increase of microRNA-4497 in human placenta is associated with early recurrent miscarriage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-021-00701-8"}], "href": "https://doi.org/10.1186/s12958-021-00701-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33579314"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33579314"}]}]}]}