MIR4499 Gene

HGNC Family Non-coding RNAs
Name microRNA 4499
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study detailed in the abstract (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "provides comprehensive insights into how the overexpression of ribose-5-phosphate isomerase A (RPIA) contributes to oncogenesis in hepatocellular carcinoma (HCC). It shows that increased RPIA levels correlate strongly with various clinical features including tumor stage, grade, size, and invasion, and that RPIA facilitates enhanced cell proliferation, colony formation, and tumor growth. These oncogenic effects appear to be mediated by the activation of ERK signaling and the concurrent inhibition of PP2A activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Notably, throughout the abstract no direct mention or investigation of MIR4499 is provided. Thus, while the document robustly outlines the role of RPIA in HCC progression, it does not offer any evidence or discussion pertaining to the function of MIR4499. Researchers interested in the role of MIR4499 will need to consult additional sources which specifically address its involvement in cellular processes or oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shih-Ci Ciou, Yu-Ting Chou, Yu-Ling Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.29361"}], "href": "https://doi.org/10.1002/ijc.29361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25429733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25429733"}]}]}]}
NCBI Gene ID 100616304
API
Download Associations
Predicted Functions View MIR4499's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4499's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4499's ARCHS4 Predicted Functions.

Functional Associations

MIR4499 has 210 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for MIR4499 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4499 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4499 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4499 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4499 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4499 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4499 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4499 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4499 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.