MIR449C Gene

HGNC Family Non-coding RNAs
Name microRNA 449c
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR‑449c‑5p plays versatile roles in regulating cellular homeostasis and tumorigenesis. In models of sepsis‐induced acute kidney injury, miR‑449c‑5p was shown to alleviate human umbilical vein endothelial cell injury by inhibiting the NF‑κB signaling pathway; mechanistically, it targets TAK1 to suppress pro‑inflammatory responses that contribute to vascular damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of breast cancer, miR‑449c‑5p has been implicated as a biomarker, with evidence suggesting it may modulate oncogenic signaling by targeting ERBB2, thereby influencing tumor progression and therapeutic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, functional studies in bladder cancer cells support a tumor‑suppressive role for miR‑449c. Stable overexpression of miR‑449c in a human bladder cancer cell line resulted in significant downregulation of c‑Myc expression, a key oncogene, underscoring its potential as a therapeutic target for modulating cancer cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qinghui Fu, Wenqiao Yu, Shuiqiao Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-449c-5p alleviates lipopolysaccharide-induced HUVECs injury via inhibiting the activation NF-κb signaling pathway by TAK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2022.03.123"}], "href": "https://doi.org/10.1016/j.molimm.2022.03.123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35421737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35421737"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li Li, Yangqiurong Zhang, Kunxian Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-449c-5p regulates the JAK-STAT pathway in inhibiting cell proliferation and invasion in human breast cancer cells by targeting ERBB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Rep (Hoboken) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cnr2.1974"}], "href": "https://doi.org/10.1002/cnr2.1974"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38351535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38351535"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pengfei Wan, Yaqin Huang, Zhi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[The establishment of 5637 bladder cancer cell line with stable overexpression of miR-449c]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27371842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27371842"}]}]}]}
Synonyms MIR-449C
NCBI Gene ID 100313923
API
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Predicted Functions View MIR449C's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR449C's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR449C's ARCHS4 Predicted Functions.

Functional Associations

MIR449C has 1,138 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR449C from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR449C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR449C gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR449C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR449C gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR449C gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR449C gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR449C gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR449C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR449C gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR449C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR449C gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR449C gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Reactome Pathways 2014 pathways involving MIR449C protein from the Reactome Pathways dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR449C gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
WikiPathways Pathways 2014 pathways involving MIR449C protein from the Wikipathways Pathways 2014 dataset.