MIR450A1 Gene

HGNC Family Non-coding RNAs
Name microRNA 450a-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies in metabolic disorders and oral squamous cell carcinoma reveal that miR‑450a expression is closely linked with altered cellular metabolism and invasive behavior. In patients with type 2 diabetes mellitus and coronary artery disease, dysregulated miR‑450a expression is associated with abnormal NADPH oxidase 4 activity and related metabolic parameters, suggesting a role in metabolic homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in oral squamous cell carcinoma, upregulation of miR‑450a impairs cell adhesion and promotes invasion by downregulating TMEM182 through a TNF‑α/ERK1/2‐dependent pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several other cancer types, miR‑450a functions predominantly as a tumor suppressor. In ovarian cancer, overexpression of miR‑450a suppresses key genes involved in the epithelial-to-mesenchymal transition and mitochondrial metabolic regulators, thereby reducing tumor migration, invasion, and enhancing anoikis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in colorectal carcinoma, the miR‑450a‑5p isoform directly targets the stem cell transcription factor SOX2, resulting in diminished cancer stem cell properties, angiogenesis, and vasculogenic mimicry."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In breast cancer, miR‑450a attenuates cell proliferation, migration, and invasion by targeting CREB1 and inhibiting the PI3K/AKT signaling cascade along with downstream matrix metalloproteinase activities."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore the context-dependent roles of miR‑450a (MIR450A1) in human disease. In certain tumors such as ovarian, colorectal, and breast cancers, miR‑450a acts as a tumor suppressor by modulating metabolic pathways and key transcription factors, thereby curbing metastatic potential. Conversely, in oral squamous cell carcinoma, its upregulation enhances oncogenic features through loss of cell adhesion and increased cellular motility. Furthermore, its altered expression in metabolic conditions hints at broader regulatory functions that may intersect with disease pathogenesis, offering promising avenues for novel therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mae Seleem, Marwa Shabayek, Heba A Ewida "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs 342 and 450 together with NOX-4 activity and their association with coronary artery disease in diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes Metab Res Rev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dmrr.3130"}], "href": "https://doi.org/10.1002/dmrr.3130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30681251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30681251"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "En-Wei Hsing, Shine-Gwo Shiah, Hsuan-Yu Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0213463"}], "href": "https://doi.org/10.1371/journal.pone.0213463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30893332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30893332"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bruna Rodrigues Muys, Josane F Sousa, Jessica Rodrigues Plaça, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-19-0490"}], "href": "https://doi.org/10.1158/0008-5472.CAN-19-0490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31101765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31101765"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiaxuan Chen, Shengyuan Chen, Linghao Zhuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of cancer stem cell properties, angiogenesis, and vasculogenic mimicry by miR-450a-5p/SOX2 axis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2361-z"}], "href": "https://doi.org/10.1038/s41419-020-2361-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32144236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32144236"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ying Zhang, Xiao-Xu Han, Xiao-Meng Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-450a exerts oncosuppressive effects in breast carcinoma by targeting CREB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12547"}], "href": "https://doi.org/10.1002/kjm2.12547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35451558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35451558"}]}]}]}
Synonyms MIRN450A1, MIRN450, HSA-MIR-450, MIRN450A-1, MIRN450-1, MIR-450A-1
NCBI Gene ID 554214
API
Download Associations
Predicted Functions View MIR450A1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR450A1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR450A1's ARCHS4 Predicted Functions.

Functional Associations

MIR450A1 has 193 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR450A1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR450A1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR450A1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR450A1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR450A1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR450A1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR450A1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR450A1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR450A1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR450A1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR450A1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.