MIR450B Gene

HGNC Family Non-coding RNAs
Name microRNA 450b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR450B, including its –3p and –5p isoforms, plays multifaceted roles in cancer biology. In rhabdomyosarcoma cells, TGF‑β1 suppresses miR‑450b‑5p, thereby inhibiting myogenic differentiation by indirectly modulating targets such as ENOX2 and PAX9, while restoration of its function relieves the differentiation block."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer cells, miR‑450b‑3p acts as a tumor repressor by directly binding the 3′‑UTR of HER3 mRNA, leading to reduced HER3 expression and enhanced sensitivity to anti‑HER2 therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In colorectal cancer (CRC), conflicting observations have been reported: one study shows that downregulation of miR‑450b‑5p leads to enhanced stemness and chemoresistance via derepression of SOX2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while another finds that elevated miR‑450b‑5p levels are associated with poor differentiation, advanced tumor stage, and activation of Wnt/β‑catenin signaling through direct targeting of SFRP2 and SIAH1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Additionally, in lung adenocarcinoma, the oncogenic long non‑coding RNA LINC00319 promotes tumor progression via the miR‑450b‑5p/EZH2 axis, and in hepatocellular carcinoma, miR‑450b‑3p exerts tumor‑suppressive effects by inhibiting PGK1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, emerging evidence in oral squamous cell carcinoma also implicates miR‑450b in cancer progression, underscoring its context‑dependent regulatory potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumorigenesis, MIR450B is pivotal in regulating differentiation and fibrogenesis. In human adipose‑derived mesenchymal stem cells, miR‑450b is upregulated during osteogenic differentiation, where it promotes osteoblast formation by directly targeting the bone morphogenetic protein BMP3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In pulmonary contexts, miR‑450b‑5p is a critical mediator within a long non‑coding RNA network: in idiopathic pulmonary fibrosis, lncRNA Hoxaas3 suppresses miR‑450b‑5p to stimulate Runx1‑driven fibrogenesis, whereas in lipopolysaccharide‐induced acute lung injury, increased miR‑450b‑5p (released upon MIR3142HG knockdown) reduces HMGB1 expression, thereby alleviating endothelial inflammation and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, alterations in MIR450B expression have broader clinical implications. In relapsing–remitting and secondary progressive multiple sclerosis, reduced serum levels of miR‑450b‑5p correlate with increased expression of ROCK2, more severe clinical disability, and progressive disease course, suggesting that miR‑450b‑5p may serve as a prognostic biomarker in inflammatory neurological disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M M Sun, J F Li, L L Guo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Targeting HER3 with miR-450b-3p suppresses breast cancer cells proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.29923"}], "href": "https://doi.org/10.4161/cbt.29923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25046105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25046105"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yinghu Jin, Zheng Jiang, Xu Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-450b-5p Suppresses Stemness and the Development of Chemoresistance by Targeting SOX2 in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2015.3120"}], "href": "https://doi.org/10.1089/dna.2015.3120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26845645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26845645"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ya-Ping Ye, Ping Wu, Chun-Cai Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11016"}], "href": "https://doi.org/10.18632/oncotarget.11016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27494869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27494869"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zeng-Wang Zhang, Jia-Jun Chen, Shi-Hui Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.01.096"}], "href": "https://doi.org/10.1016/j.gene.2018.01.096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29408583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29408583"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zide Chen, Wenhang Zhuang, Zeju Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-450b-3p inhibits cell growth by targeting phosphoglycerate kinase 1 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29196"}], "href": "https://doi.org/10.1002/jcb.29196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31222833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31222833"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaotang Wang, Xiaocui Nie, Guoqiang Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/odi.14407"}], "href": "https://doi.org/10.1111/odi.14407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36251494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36251494"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Linyuan Fan, Junfen Fan, Yan Liu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA Hoxaas3 promotes lung fibroblast activation and fibrosis by targeting miR-450b-5p to regulate Runx1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02889-w"}], "href": "https://doi.org/10.1038/s41419-020-02889-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32848140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32848140"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiaolei Gong, Limin Zhu, Jinlong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR3142HG promotes lipopolysaccharide-induced acute lung injury by regulating miR-450b-5p/HMGB1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-021-04209-y"}], "href": "https://doi.org/10.1007/s11010-021-04209-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34338955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34338955"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Samar H Ibrahim, Karim M El-Mehdawy, Mae Seleem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum ROCK2, miR-300 and miR-450b-5p levels in two different clinical phenotypes of multiple sclerosis: Relation to patient disability and disease progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jneuroim.2020.577356"}], "href": "https://doi.org/10.1016/j.jneuroim.2020.577356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32781341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32781341"}]}]}]}
Synonyms MIR-450B, MIRN450B
NCBI Gene ID 100126302
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Download Associations
Predicted Functions View MIR450B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR450B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR450B's ARCHS4 Predicted Functions.

Functional Associations

MIR450B has 221 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR450B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR450B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR450B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR450B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR450B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR450B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR450B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR450B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR450B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR450B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR450B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR450B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR450B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
WikiPathways Pathways 2014 pathways involving MIR450B protein from the Wikipathways Pathways 2014 dataset.