{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTEAD4 is a pivotal transcription factor that orchestrates early cell‐fate decisions in mammalian embryos. During preimplantation development, TEAD4 regulates the specification of the trophectoderm by activating lineage‐specific gene programs and ensuring proper blastocoel formation. In doing so, it integrates signals from upstream regulators – including AP‐2γ, RhoA, and other Hippo pathway components – to demarcate the extraembryonic fate from the inner cell mass and to mitigate oxidative stress associated with increased mitochondrial activity. These studies demonstrate that, by controlling transcriptional programs, TEAD4 is essential for proper early embryogenesis and energy homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn differentiating tissues, TEAD4 operates within a complex network of transcriptional regulators and co‐activators—including YAP1/TAZ, VGLL proteins, and related factors—to modulate cellular processes such as myogenic differentiation, vascular development, and osteoclastogenesis. It governs gene expression programs that balance proliferation with differentiation and even influences mitochondrial function by facilitating oxidative phosphorylation. Moreover, TEAD4 function is modulated by epigenetic regulators and by its interaction with other transcription factors (for example, AP‐1 and RTEF‐1), thereby tuning cell‐internal signaling pathways in diverse contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther, TEAD4 contributes to later developmental processes and tissue‐specific functions by helping establish cellular polarity and refining gene expression networks during organogenesis. Its activity is implicated in systems as diverse as bile duct morphogenesis, muscle regeneration, and the maintenance of pluripotency and lineage divergence. Despite the extensive characterization of TEAD4 and its collaborators across multiple biological contexts, none of the abstracts provided directly explore or mention MIR4522. Therefore, while the regulatory circuits controlled by TEAD4 have been well mapped, the functional role of MIR4522 within these networks remains undetermined."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Yasunami, K Suzuki, H Ohkubo "}, {"type": "b", "children": [{"type": "t", "text": "A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1996)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/bbrc.1996.1667"}], "href": "https://doi.org/10.1006/bbrc.1996.1667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "8920920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/8920920"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Binoy Appukuttan, Trevor J McFarland, Michael H Davies, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.003608"}], "href": "https://doi.org/10.1074/jbc.RA118.003608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30209132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30209132"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Tristan Frum, Jennifer L Watts, Amy Ralston "}, {"type": "b", "children": [{"type": "t", "text": "TEAD4, YAP1 and WWTR1 prevent the premature onset of pluripotency prior to the 16-cell stage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.179861"}], "href": "https://doi.org/10.1242/dev.179861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31444221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31444221"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Merlin Airik, Markus Schüler, Blake McCourt, et al. 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