{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into cervical cancer have revealed that miR-4524b-5p plays a crucial role in tumor progression. Elevated expression of miR-4524b-5p was detected in relapsed cervical cancer specimens, and functional studies demonstrated that its overexpression promotes enhanced migration and invasion of cervical cancer cells. Mechanistically, miR-4524b-5p exerts these protumorigenic effects by directly targeting and suppressing the tumor suppressor gene WTX, thereby influencing the downstream expression of β-catenin—a key mediator in cellular adhesion and signaling pathways. These findings establish a novel miR-4524b-5p/WTX/β-catenin regulatory axis that may serve as a promising therapeutic target for cervical cancer treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tong Li, Wenjuan Zhou, Yimin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4524b-5p/WTX/β-catenin axis functions as a regulator of metastasis in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0214822"}], "href": "https://doi.org/10.1371/journal.pone.0214822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30939162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30939162"}]}]}]}