{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings in human umbilical vein endothelial cells have demonstrated that overexpression of a novel microRNA—designated miR‐14530 in this study—leads to a marked suppression of cell proliferation and an enhancement of apoptosis. This activity appears to be mediated via the upregulation of RASA1, a gene that, upon increased expression, modulates both the extracellular signal‐regulated kinase (ERK)/mitogen‑activated protein kinase (MAPK) and phosphoinositide‑3‑kinase (PI3K)/AKT signaling pathways. Although the precise mechanism by which miR‐14530 enhances RASA1 protein levels remains to be fully elucidated, these observations underscore its potential role as a negative regulator of cellular growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, studies on human gliomas have revealed that miR‐4530 is significantly down‑regulated in clinical tissues and glioma cell lines, such as U251 and T98G. Upon forced overexpression, miR‐4530 exerts potent tumor‑suppressive effects, including the inhibition of cell proliferation, colony formation, migration, and invasion, as well as the promotion of apoptotic cell death. These anti‑tumor activities are achieved through the direct targeting of RTEL1, a gene whose elevated expression counteracts the suppressive influence of miR‑4530 on malignant phenotypes, a finding further supported by in vivo xenograft models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, the data from these studies highlight the critical role of these microRNAs in controlling cellular homeostasis via the regulation of key target genes. While one investigation demonstrates that miR‐14530 can inhibit endothelial cell growth through modulation of RASA1 and its downstream ERK/MAPK and PI3K/AKT pathways, another study establishes that miR‐4530 functions as a tumor suppressor in gliomas by targeting RTEL1. These complementary findings suggest that modulation of such microRNAs could represent a promising therapeutic strategy in conditions characterized by aberrant cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Jing, Hong Li, Tao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑4530 suppresses cell proliferation and induces apoptosis by targeting RASA1 in human umbilical vein endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10000"}], "href": "https://doi.org/10.3892/mmr.2019.10000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30864691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30864691"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tuo Wang, Yan Zhang, Bo Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4530 inhibits the malignant biological behaviors of human glioma cells by directly targeting RTEL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmaa126"}], "href": "https://doi.org/10.1093/abbs/gmaa126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33200790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33200790"}]}]}]}