{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐4534 (miR‐4534) functions as an oncogenic regulator in prostate cancer, where its expression is elevated compared with that in normal tissues that exhibit hypermethylation at the miR‐4534 locus"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " miR‐4534 promotes tumorigenesis at least in part by downregulating the tumor suppressor gene PTEN. In prostate cancer cell models, knockdown of miR‐4534 impaired proliferation, migration, and invasion, and induced G0/G1 cell cycle arrest and apoptosis, while its ectopic overexpression in non‐cancerous prostate cells induced pro‐cancerous characteristics. These findings, corroborated by xenograft mouse models showing reduced tumor growth following miR‐4534 suppression, suggest that miR‐4534 is a key modulator of the PTEN pathway in prostate cancer and may represent an attractive candidate for diagnostic and therapeutic targeting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hannah Nip, Altaf A Dar, Sharanjot Saini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12031"}], "href": "https://doi.org/10.18632/oncotarget.12031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27634912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27634912"}]}]}]}