{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nGrowth factor independence‐1 (Gfi1) is a zinc‐finger transcriptional repressor that plays an essential and multifaceted role in early hematopoiesis and lymphoid as well as myeloid lineage decisions. In hematopoietic stem cells, Gfi1 restricts proliferation, preserves self‐renewal, and protects against stress‐induced apoptosis by repressing target genes such as Bax, thereby maintaining a balanced progenitor pool (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, during T cell development and activation, Gfi1 is dynamically expressed to enforce proper lineage commitment—bolstering Th2 expansion while inhibiting alternative fates such as Th17 and inducible T regulatory cell differentiation—by modulating key transcription factors and downstream effectors (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "8"}]}, {"type": "t", "text": " In addition, Gfi1 partners with chromatin-modifying factors such as LSD1 and CoREST, thereby regulating epigenetic landscapes essential for proper expression of lineage-specific genes, which is critical not only in progenitor cells but also in mature immune cells responding to inflammatory stimuli (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central role in blood cell development, Gfi1 is also critical in determining non-hematopoietic cell fates. In neural and sensory systems, for example, Gfi1 is expressed in developing inner ear hair cells and neurons and is indispensable for proper differentiation and survival of cochlear hair cells; its loss not only perturbs normal cell identity but also leads to apoptosis and aberrant innervation that underlies hearing deficits (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "32"}]}, {"type": "t", "text": " Moreover, Gfi1 exerts a pivotal role in the regulation of progenitor cell fate in acute leukemias and myeloproliferative disorders through direct repression of oncogenic programs and modulation of cytokine responses, and it contributes to the polarization of macrophages that can support malignant cell expansion (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "33", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent studies extending into regenerative medicine have further highlighted Gfi1’s potential as a target for reprogramming strategies. In the context of the cochlea, combinatorial overexpression of Gfi1 with other hair cell–specific transcription factors (such as Atoh1 and Pou4f3) significantly enhances the efficiency of generating new, functional hair cells that exhibit mature electrophysiological properties—a promising approach for future hearing restoration therapies (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Holger Karsunky, Hui Zeng, Thorsten Schmidt, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0608981103"}], "href": "https://doi.org/10.1073/pnas.0608981103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17116877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17116877"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Maria De La Luz Sierra, Paola Gasperini, Peter J McCormick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-03-081448"}], "href": "https://doi.org/10.1182/blood-2007-03-081448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17596540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17596540"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shireen Saleque, Jonghwan Kim, Heather M Rooke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.06.039"}], "href": "https://doi.org/10.1016/j.molcel.2007.06.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17707228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17707228"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Denise Pargmann, Raif Yücel, Christian Kosan, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2007.12.020"}], "href": "https://doi.org/10.1016/j.immuni.2007.12.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18328744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18328744"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Anmol Chandele, Nikhil S Joshi, Jinfang Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.8.5309"}], "href": "https://doi.org/10.4049/jimmunol.180.8.5309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18390712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18390712"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Chinavenmeni S Velu, Avinash M Baktula, H Leighton Grimes "}, {"type": "b", "children": [{"type": "t", "text": "Gfi1 regulates miR-21 and miR-196b to control myelopoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-11-190215"}], "href": "https://doi.org/10.1182/blood-2008-11-190215"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19278956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19278956"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Shane R Horman, Chinavenmeni S Velu, Aditya Chaubey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gfi1 integrates progenitor versus granulocytic transcriptional programming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-09-179747"}], "href": "https://doi.org/10.1182/blood-2008-09-179747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19346496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19346496"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kenji Ichiyama, Masayuki Hashimoto, Takashi Sekiya, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-10-386094"}], "href": "https://doi.org/10.1182/blood-2011-10-386094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22668850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22668850"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Diana Ordoñez-Rueda, Friederike Jönsson, David A Mancardi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.201242589"}], "href": "https://doi.org/10.1002/eji.201242589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22684987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22684987"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Cyrus Khandanpour, James D Phelan, Lothar Vassen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2013.01.011"}], "href": "https://doi.org/10.1016/j.ccr.2013.01.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23410974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23410974"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Weiming Ouyang, Soyoung A Oh, Qian Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2013.07.016"}], "href": "https://doi.org/10.1016/j.immuni.2013.07.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23932572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23932572"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "James D Phelan, Ingrid Saba, Hui Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1003713"}], "href": "https://doi.org/10.1371/journal.pgen.1003713"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24068942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24068942"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Paul A Northcott, Catherine Lee, Thomas Zichner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature13379"}], "href": "https://doi.org/10.1038/nature13379"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25043047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25043047"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Roshana Thambyrajah, Milena Mazan, Rahima Patel, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/imm.12580"}], "href": "https://doi.org/10.1111/imm.12580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26749286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26749286"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Yu-Gang Wang, Xin-Hua Qu, Ying Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2016.06.004"}], "href": "https://doi.org/10.1016/j.cellsig.2016.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27283242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27283242"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "BaoHan T Vo, Chunliang Li, Marc A Morgan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.02.073"}], "href": "https://doi.org/10.1016/j.celrep.2017.02.073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28329683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28329683"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Jung-Mi Lee, Vinothini Govindarajah, Bryan Goddard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Gfi1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20170690"}], "href": "https://doi.org/10.1084/jem.20170690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29282250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29282250"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Sungsu Lee, Jae-Jun Song, Lisa A Beyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-78167-8"}], "href": "https://doi.org/10.1038/s41598-020-78167-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33293609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33293609"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Amrita A Iyer, Ishwar Hosamani, John D Nguyen, et al. 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