{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe abstract from"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "focuses on the characterization and functional importance of HAT-L4, a type II transmembrane serine protease implicated in maintaining epidermal barrier integrity. In this study, HAT-L4 was shown to be expressed on the surface of epithelial cells in various tissues such as the skin, esophagus, trachea, and exocrine glands, with marked expression in keratinocytes and sebaceous glands. Functional analyses using a knockout mouse model revealed that loss of HAT-L4 does not affect viability or fertility, yet it compromises the skin’s barrier function, leading to greater trans-epidermal body fluid loss in neonates and increased water consumption in adults. Notably, while this research comprehensively details HAT-L4’s role in protecting against fluid loss and maintaining skin integrity, it does not address or provide information regarding MIR4538. Therefore, no functional insights into MIR4538 can be inferred from the content of this abstract.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhiwei Zhang, Yae Hu, Ruhong Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep45262"}], "href": "https://doi.org/10.1038/srep45262"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28338078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28338078"}]}]}]}