{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐454, particularly its –3p species, displays potent oncogenic functions in a variety of human cancers. In several studies of breast, prostate, gastric, colorectal, cervical, and nasopharyngeal carcinomas, for example, overexpression of miR‐454 was shown to promote cell proliferation, migration, invasion, epithelial–mesenchymal transition and chemoresistance by directly inhibiting key tumor‐suppressive genes (such as RPRD1A, CHD5, CYLD, TRIM3, and NDRG2) and concomitantly activating oncogenic pathways including Wnt/β‐catenin signaling. In hepatocellular carcinoma, elevated miR‐454 levels in tumor‐initiating cells further contributed to self‐renewal and sorafenib resistance, positioning this miRNA as a potential prognostic indicator as well as a therapeutic target in these settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, a number of investigations in glioblastoma, non–small cell lung cancer, oral squamous cell carcinoma, anaplastic thyroid carcinoma, neuroblastoma, and even colon cancer have demonstrated that miR‐454 can function as a tumor suppressor. In these studies, ectopic restoration of miR‐454 expression impaired cell cycle progression and reduced cell proliferation, migration, and invasion by targeting oncogenic mediators including PDK1, NFATc2, CPEB1, and NR3C2. These findings underscore the context‐dependent functions of miR‐454, which in certain tumor types counteract malignant transformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncology, miR‐454 has been implicated in diverse non‐malignant conditions. In studies of pre‐eclampsia, decreased miR‐454 levels in placental tissues were linked to impaired trophoblast proliferation and invasion—phenomena mediated in part by targets such as ALK7 and EPHB4—thereby contributing to disease pathogenesis. Similarly, in models of heart failure and ischemic stroke, miR‐454 exerts cardioprotective and neuroprotective effects by modulating apoptotic pathways and oxidative stress (through regulators like NEDD4‐2/TrkA and NOX4). In vascular settings, including sickle cell disease and hereditary hemorrhagic telangiectasia, miR‐454 negatively regulates vasoactive and profibrotic factors (ET‐1 and PAI‐1) and supports proper angiogenic function, while its downregulation is associated with bone invasion in pituitary adenomas and altered disease activity in multiple sclerosis. Notably, a potential role in acute myeloid leukemia has also been suggested, although its precise contributions in this context remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hong-Liang Liang, Ai-Ping Hu, Sen-Lin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-454 prompts cell proliferation of human colorectal cancer cells by repressing CYLD expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2015.16.6.2397"}], "href": "https://doi.org/10.7314/apjcp.2015.16.6.2397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25824771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25824771"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhi-Gang Cao, Jun-Jing Li, Ling Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of microRNA-454 is associated with poor prognosis in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11764"}], "href": "https://doi.org/10.18632/oncotarget.11764"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27588500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27588500"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qiang Fu, Yanyao Gao, Fan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of microRNA-454 impedes the proliferation and invasion of prostate cancer cells by promoting N-myc downstream-regulated gene 2 and inhibiting WNT/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.10.115"}], "href": "https://doi.org/10.1016/j.biopha.2017.10.115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29080452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29080452"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guangru Xu, Hongxing Zhu, Minghui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone deacetylase 3 is associated with gastric cancer cell growth via the miR-454-mediated targeting of CHD5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2017.3225"}], "href": "https://doi.org/10.3892/ijmm.2017.3225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29115379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29115379"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Liangliang Ren, Han Chen, Junwei Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-454-3p-Mediated Wnt/β-catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.29055"}], "href": "https://doi.org/10.7150/thno.29055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30809286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30809286"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yu Song, Qisang Guo, Shujun Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.06.126"}], "href": "https://doi.org/10.1016/j.bbrc.2019.06.126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31270028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31270028"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhengqing Lei, Xuewu Tang, Anfeng Si, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-454 promotes liver tumor-initiating cell expansion by regulating SOCS6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.111955"}], "href": "https://doi.org/10.1016/j.yexcr.2020.111955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32165166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32165166"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Feng-Jie Lin, Xian-Dong Lin, Lu-Ying Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA HOXA11-AS Modulates the Resistance of Nasopharyngeal Carcinoma Cells to Cisplatin via miR-454-3p/c-Met."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2020.0133"}], "href": "https://doi.org/10.14348/molcells.2020.0133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33115978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33115978"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "YinYing Wu, Bo Zhu, Yanli Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG1 stimulates ovarian cancer progression by modulating expression of miR-454 and ZEB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12932"}], "href": "https://doi.org/10.1002/1878-0261.12932"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33641229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33641229"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Cui-Ping Wang, Yong-Zheng Yu, Hui Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑454‑5p promotes breast cancer progression by inducing epithelial‑mesenchymal transition via targeting the FoxJ2/E‑cadherin axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8078"}], "href": "https://doi.org/10.3892/or.2021.8078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33982790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33982790"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Raghu Aarthy, Arunagiri Kuha Deva Magendhra Rao, Krishna Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alteration of miR-362-5p and miR-454-3p expression elicits diverse responses in breast cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-021-06873-1"}], "href": "https://doi.org/10.1007/s11033-021-06873-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34727290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34727290"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jingjing Xu, Meishun Hu, Yang Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biotechnol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12033-023-00706-1"}], "href": "https://doi.org/10.1007/s12033-023-00706-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36943627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36943627"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Baojun Fang, Jianxin Zhu, Yunhua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-454 inhibited cell proliferation of human glioblastoma cells by suppressing PDK1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2015.07.029"}], "href": "https://doi.org/10.1016/j.biopha.2015.07.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26297548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26297548"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xiaobo Hui, Shiming Zhang, Yanping Wang "}, {"type": "b", "children": [{"type": "t", "text": "miR‑454‑3p suppresses cell migration and invasion by targeting CPEB1 in human glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9386"}], "href": "https://doi.org/10.3892/mmr.2018.9386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30106109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30106109"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wenhua Li, Yun Feng, Zhenzeng Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of miR-454-3p and its effect on proliferation, invasion and metastasis of colon cancer]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2018.12.04"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2018.12.04"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30613008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30613008"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jiandong Zuo, Huimei Yu, Peng Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-454-3p exerts tumor-suppressive functions by down-regulation of NFATc2 in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.06.008"}], "href": "https://doi.org/10.1016/j.gene.2019.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31181312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31181312"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jing-Yu Guo, Yu-Kun Wang, Bo Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-454 performs tumor-promoting effects in oral squamous cell carcinoma via reducing NR3C2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Pathol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jop.13015"}], "href": "https://doi.org/10.1111/jop.13015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32170966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32170966"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Hongliang Liao, Yaqin Liang, Lin Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑454‑3p inhibits non‑small cell lung cancer cell proliferation and metastasis by targeting TGFB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8018"}], "href": "https://doi.org/10.3892/or.2021.8018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33760169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33760169"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Qian Zhang, Jingli Wei, Na Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00839 Promotes Neuroblastoma Progression by Sponging miR-454-3p to Up-Regulate NEUROD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11064-022-03613-0"}], "href": "https://doi.org/10.1007/s11064-022-03613-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35606572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35606572"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yang Wu, Jihua Yang, Honglai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA H19 Influences Cellular Activities via the miR-454-3p/BHLHE40 Axis in Anaplastic Thyroid Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Metab Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/a-2196-3511"}], "href": "https://doi.org/10.1055/a-2196-3511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38052232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38052232"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Caryn S Gonsalves, Chen Li, Punam Malik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peroxisome proliferator-activated receptor-α-mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulates endothelin-1 and PAI-1 expression in sickle cell disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20150190"}], "href": "https://doi.org/10.1042/BSR20150190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26460070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26460070"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Furong Wang, Jin Yan "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-454 is involved in regulating trophoblast cell proliferation, apoptosis, and invasion in preeclampsia by modulating the expression of ephrin receptor B4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.08.055"}], "href": "https://doi.org/10.1016/j.biopha.2018.08.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30138897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30138897"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ziyun Shi, Kaie She, Hong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-454 contributes to sustaining the proliferation and invasion of trophoblast cells through inhibiting Nodal/ALK7 signaling in pre-eclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chem Biol Interact (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cbi.2018.10.012"}], "href": "https://doi.org/10.1016/j.cbi.2018.10.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30367833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30367833"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yaowen Wang, Wei Pan, Xinyu Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-454-mediated NEDD4-2/TrkA/cAMP axis in heart failure: Mechanisms and cardioprotective implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16491"}], "href": "https://doi.org/10.1111/jcmm.16491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33949117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33949117"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Hai-Bo Zhu, Bin Li, Jing Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MEG8 promotes TNF-α expression by sponging miR-454-3p in bone-invasive pituitary adenomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203048"}], "href": "https://doi.org/10.18632/aging.203048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34016788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34016788"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Amira A Moharram, Hanaa A Amer, Salwa I Bakr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between circulating MicroRNAs (hsa-miR-92a-1* and hsa-miR-454) and multiple sclerosis phenotypes and activity status."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Egypt J Immunol (2022)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35436050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35436050"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Tao Zhang, Haiping Han, Yan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-454 modulates the oxidative stress and neuronal apoptosis after cerebral ischemia/reperfusion injury via targeting NADPH oxidase 4 (NOX4)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23153"}], "href": "https://doi.org/10.1002/jbt.23153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36043333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36043333"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Anthony Cannavicci, Qiuwang Zhang, Michael J B Kutryk "}, {"type": "b", "children": [{"type": "t", "text": "The Potential Role of MiRs-139-5p and -454-3p in Endoglin-Knockdown-Induced Angiogenic Dysfunction in HUVECs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24054916"}], "href": "https://doi.org/10.3390/ijms24054916"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36902347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36902347"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Xiao Wang, Liang Zhong, Wenran Dan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-454-3p promotes apoptosis and autophagy of AML cells by targeting ZEB2 and regulating AKT/mTOR pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hematology (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/16078454.2023.2223874"}], "href": "https://doi.org/10.1080/16078454.2023.2223874"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37313984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37313984"}]}]}]}