{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe two studies provided focus on elucidating the roles of PEX3 in peroxisome biogenesis‐related pathways and their physiological consequences on hearing and cardiac repair. In the first study, mice bearing mutations in Pex3 displayed normal auditory development followed by early‐onset hearing loss. This deficit was linked to disrupted synaptic integrity beneath the inner hair cells and a local reduction in plasmalogen levels in the inner ear, underscoring the critical, localized role of peroxisomal function for proper cochlear physiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the second study, selective knockout of PEX3 in cardiomyocytes disturbed redox homeostasis and impaired myocardial regenerative repair. Mechanistically, these alterations were associated with compromised plasmalogen metabolism that hindered the activation of the AKT/GSK3β signaling cascade, thereby affecting cardiac proliferation and repair processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that neither abstract mentions or provides data regarding MIR4640. Consequently, while the studies clearly delineate the critical functions of PEX3 in the regulation of plasmalogen metabolism and its impact on auditory and cardiac systems, they do not offer any insights into the role or function of MIR4640.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rafael M Kochaj, Elisa Martelletti, Neil J Ingham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Effect of a "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Pex3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Mutation on Hearing and Lipid Content of the Inner Ear."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells11203206"}], "href": "https://doi.org/10.3390/cells11203206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36291074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36291074"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jia-Teng Sun, Zi-Mu Wang, Liu-Hua Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-024-06483-0"}], "href": "https://doi.org/10.1038/s42003-024-06483-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38951640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38951640"}]}]}]}