{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn studies investigating pancreatobiliary tract cancer, miR‐4644 has been identified as a promising non‐invasive biomarker. Elevated levels of miR‐4644 in salivary exosomes—along with other miRNAs—were found to discriminate cancer patients from healthy subjects, suggesting its potential utility for early detection in this highly fatal disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer, miR‐4644 is mechanistically involved in a competing endogenous RNA network. Specifically, the long non‐coding RNA ELFN1‐AS1 acts as a sponge for miR‐4644, thereby relieving repression of its target TRIM44. As a result, increased TRIM44 expression promotes enhanced proliferation and migration of cancer cells, implicating miR‐4644 in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in cancer, miR‐4644 forms part of a regulatory axis in polycystic ovarian syndrome (PCOS). Here, exosomal circular RNA (circ_0008285) regulates the miR‐4644/low‐density lipoprotein receptor (LDLR) axis within the follicular fluid microenvironment, indicating that miR‐4644 may contribute to the molecular pathogenesis of PCOS."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tatsuya Machida, Takaaki Tomofuji, Takayuki Maruyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑1246 and miR‑4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5021"}], "href": "https://doi.org/10.3892/or.2016.5021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27573701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27573701"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ren Lei, Liuchun Feng, Deng Hong "}, {"type": "b", "children": [{"type": "t", "text": "ELFN1-AS1 accelerates the proliferation and migration of colorectal cancer via regulation of miR-4644/TRIM44 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-190559"}], "href": "https://doi.org/10.3233/CBM-190559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31929141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31929141"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li Yu, Chen Wang, Doudou Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Ovarian Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13048-023-01199-x"}], "href": "https://doi.org/10.1186/s13048-023-01199-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37322492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37322492"}]}]}]}