{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nDiabetic kidney disease (DKD) is marked by podocyte injury, which is a key event driving disease progression. In DKD, miR-4645-3p is significantly downregulated in podocytes grown under high-glucose conditions and in kidney tissues from both patients and diabetic mice. Loss of miR-4645-3p expression under normal glucose conditions precipitates mitochondrial damage and increases podocyte apoptosis, whereas overexpression under high-glucose conditions protects against these deleterious effects by preserving mitochondrial integrity and cell viability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, miR-4645-3p confers its cytoprotective role by directly targeting and inhibiting cyclin-dependent kinase 5 (Cdk5), a mediator implicated in podocyte injury. Consistent with these findings, treatment with exogenous miR-4645-3p in diabetic mouse models effectively ameliorated podocyte injury, reduced proteinuria, and improved renal function, suggesting that sustaining miR-4645-3p expression in podocytes may offer a promising therapeutic strategy for DKD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yue Zhang, Shunjie Xia, Xiaoxi Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4645-3p attenuates podocyte injury and mitochondrial dysfunction in diabetic kidney disease by targeting Cdk5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202300357RR"}], "href": "https://doi.org/10.1096/fj.202300357RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38742811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38742811"}]}]}]}