{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn malignant meningioma, miR-4652-3p has been identified as a key regulatory molecule that is sponged by the long noncoding RNA LINC00702. This interaction prevents miR-4652-3p from inhibiting its target, ZEB1, thereby contributing to the upregulation of ZEB1 and subsequent activation of the Wnt/β-catenin signaling pathway. As a result, LINC00702-mediated downregulation of miR-4652-3p facilitates enhanced cell proliferation and migration in malignant meningioma cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn nasopharyngeal carcinoma, miR-4652-3p is upregulated downstream of the transcriptional repressor SPEN, which acts through the PI3K/AKT/c-JUN signaling cascade. Elevated levels of miR-4652-3p lead to the suppression of HIPK2, a tumor suppressor gene that normally attenuates epithelial-mesenchymal transition (EMT). The resulting decrease in HIPK2 expression contributes to increased tumor cell migration, invasion, and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung squamous cell carcinoma, a variant of miR-4652 (miR-4652-5p) is overexpressed and functions as an oncogenic driver by directly targeting RND1. Downregulation of RND1 by miR-4652-5p reduces its inhibitory effects on cell adhesion and proliferation, thereby promoting enhanced cell growth, migration, and invasion in tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tengfei Li, Jianzhuang Ren, Ji Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00702/miR-4652-3p/ZEB1 axis promotes the progression of malignant meningioma through activating Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.108718"}], "href": "https://doi.org/10.1016/j.biopha.2019.108718"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30849635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30849635"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Li, Yumin Lv, Chao Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2699-2"}], "href": "https://doi.org/10.1038/s41419-020-2699-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32641685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32641685"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yafu Zhou, Jianhua Yan, Huiguo Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4652-5p Targets RND1 to Regulate Cell Adhesion and Promote Lung Squamous Cell Carcinoma Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Biochem Biotechnol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12010-022-03897-6"}], "href": "https://doi.org/10.1007/s12010-022-03897-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35334070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35334070"}]}]}]}