MIR4657 Gene

HGNC Family Non-coding RNAs
Name microRNA 4657
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In skeletal muscle, Hesr1 and Hesr3 are crucial during postnatal development for establishing and maintaining a pool of undifferentiated, quiescent satellite cells by suppressing premature myogenic differentiation; moreover, under conditions of mechanical overload, satellite cells rely on sustained HeyL expression to inhibit MyoD, thereby promoting proliferation, myonuclear accretion, and indirectly supporting angiogenic adaptations."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn neural progenitor cells, HeyL exhibits an atypical role relative to its Hes/Hey counterparts by actively promoting neuronal differentiation through activation of proneural genes such as neurogenin2. In parallel, within muscle stem cells, HeyL can partner with Hes1 to synergistically inhibit myogenic differentiation, highlighting its context‐dependent regulatory versatility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the mammary gland, HEYL functions as an intermediary between Notch and TGFβ signaling. By binding to TGFβ-activated Smads and repressing TGFβ activity, HEYL contributes to proper mammary gland development and, when aberrantly expressed, can promote breast tumorigenesis through deregulation of cell cycle regulators such as Mybl2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, although Notch activation in osteoblasts robustly induces a spectrum of effectors including HeyL, studies in HeyL-null mice demonstrate that HeyL is largely dispensable for skeletal microarchitecture, implying that redundancy within the Notch effector network ensures skeletal homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWhile the provided abstracts do not explicitly mention MIR4657, the molecular themes they highlight suggest that if MIR4657 were to be implicated in similar regulatory circuits, it might be expected to influence cell fate decisions in a context-dependent manner—integrating signals from Notch and other pathways to modulate proliferation, differentiation, and tissue homeostasis across muscle, neural, and mammary systems. This integrative role would be analogous to the multifaceted actions exhibited by the Hey/Hes family members described above."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "So-ichiro Fukada, Masahiko Yamaguchi, Hiroki Kokubo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.067165"}], "href": "https://doi.org/10.1242/dev.067165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21989910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21989910"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sumiaki Fukuda, Akihiro Kaneshige, Takayuki Kaji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.48284"}], "href": "https://doi.org/10.7554/eLife.48284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31545169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31545169"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Satoru Ato, So-Ichiro Fukada, Hiroki Kokubo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Implication of satellite cell behaviors in capillary growth via VEGF expression-independent mechanism in response to mechanical loading in HeyL-null mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00343.2021"}], "href": "https://doi.org/10.1152/ajpcell.00343.2021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35020502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35020502"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ali Jalali, Alexander G Bassuk, Lixin Kan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HeyL promotes neuronal differentiation of neural progenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.22562"}], "href": "https://doi.org/10.1002/jnr.22562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21259317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21259317"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yu-Taro Noguchi, Miki Nakamura, Nobumasa Hino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.163618"}], "href": "https://doi.org/10.1242/dev.163618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30745427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30745427"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Liangfeng Han, Adam Diehl, Nguyen K Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-0816"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-0816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25217524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25217524"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sonia Brahim, Ana-Maria Negulescu, Clara Geneste, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-05674-7"}], "href": "https://doi.org/10.1038/s41419-023-05674-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36854682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36854682"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ernesto Canalis, Stefano Zanotti "}, {"type": "b", "children": [{"type": "t", "text": "Hairy and Enhancer of Split-Related With YRPW Motif-Like (HeyL) Is Dispensable for Bone Remodeling in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.25859"}], "href": "https://doi.org/10.1002/jcb.25859"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28019674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28019674"}]}]}]}
Synonyms MIR-4657
NCBI Gene ID 100616393
API
Download Associations
Predicted Functions View MIR4657's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4657's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4657's ARCHS4 Predicted Functions.

Functional Associations

MIR4657 has 719 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4657 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4657 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4657 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR4657 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4657 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4657 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4657 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4657 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR4657 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4657 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.