{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe body of work summarized in these abstracts provides a comprehensive view of the multifaceted roles played by Eph receptor tyrosine kinases and their ephrin ligands in diverse biological processes including axon guidance, synaptic plasticity, tissue regeneration, angiogenesis, immune cell development, and tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": " These studies detail how Eph–ephrin interactions modulate cell–cell adhesion and repulsion, thereby orchestrating coordinated cellular responses—from guiding regenerating axons after peripheral nerve injury to constraining proliferative signals in the intestinal stem cell niche and regulating synaptic organization in the central nervous system."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "15"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, several of these studies have underscored the importance of post‐transcriptional regulators—specifically, microRNAs—in fine‐tuning Eph receptor signaling cascades. For example, microRNA profiling in colorectal cancer models has revealed that distinct miRNA networks (including species such as miR‑31 and miR‑423‑5p) interact with EphA2/EphB2 pathways, thereby influencing stem-like features and tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "22"}]}, {"type": "t", "text": " Likewise, in neurological settings, EphB2 levels have been linked to synaptic function and cognitive resilience in Alzheimer’s disease models, further implying that microRNA-mediated regulation is a critical component of these signaling networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "25"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDespite the extensive evidence detailing the modulation of Eph–ephrin signaling by various microRNAs, none of the abstracts surveyed here directly mention or characterize MIR4658. In light of the documented roles of other microRNAs in controlling the expression and signaling outputs of Eph receptors, it is plausible to hypothesize that MIR4658 may similarly function as a post‐transcriptional regulator within these networks. If expressed in relevant tissues, MIR4658 could potentially downregulate the levels of Eph receptors or their downstream mediators, thereby influencing key processes such as cell migration, axonal pathfinding, synaptic maturation, and even pathological states like cancer and neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "35"}]}, {"type": "t", "text": " Overall, while the direct functional role of MIR4658 remains to be elucidated, these collective findings advocate for further investigation of MIR4658 as a putative microRNA modulator of Eph/ephrin-dependent developmental and pathophysiological processes.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J P Himanen, K R Rajashankar, M Lackmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of an Eph receptor-ephrin complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/414933a"}], "href": "https://doi.org/10.1038/414933a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11780069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11780069"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amparo Palmer, Manuel Zimmer, Kai S Erdmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(02)00488-4"}], "href": "https://doi.org/10.1016/s1097-2765(02"}, {"type": "t", "text": "00488-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11983165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11983165"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiefei Tong, Sabine Elowe, Piers Nash, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208972200"}], "href": "https://doi.org/10.1074/jbc.M208972200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12486127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12486127"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Manuel Zimmer, Amparo Palmer, Jenny Köhler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1045"}], "href": "https://doi.org/10.1038/ncb1045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12973358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12973358"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christopher Dravis, Nobuhiko Yokoyama, Michael J Chumley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2004.03.027"}], "href": "https://doi.org/10.1016/j.ydbio.2004.03.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15223334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15223334"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Johan Holmberg, Maria Genander, Michael M Halford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB receptors coordinate migration and proliferation in the intestinal stem cell niche."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2006.04.030"}], "href": "https://doi.org/10.1016/j.cell.2006.04.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16777604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16777604"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "David Alfaro, José J García-Ceca, Teresa Cejalvo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphrinB1-EphB signaling regulates thymocyte-epithelium interactions involved in functional T cell development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200737097"}], "href": "https://doi.org/10.1002/eji.200737097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17668899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17668899"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Farima Bouzioukh, George A Wilkinson, Giselind Adelmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine phosphorylation sites in ephrinB2 are required for hippocampal long-term potentiation but not long-term depression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3393-07.2007"}], "href": "https://doi.org/10.1523/JNEUROSCI.3393-07.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17942722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17942722"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kai-Ti Lin, Slawomir Sloniowski, Douglas W Ethell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804401200"}], "href": "https://doi.org/10.1074/jbc.M804401200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18713744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18713744"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Alexei Poliakov, Maria L Cotrina, Andrea Pasini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200807151"}], "href": "https://doi.org/10.1083/jcb.200807151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19047466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19047466"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yang Shi, Crystal G Pontrello, Kathryn A DeFea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4681-08.2009"}], "href": "https://doi.org/10.1523/JNEUROSCI.4681-08.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19553453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19553453"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ana María Simón, Rakel López de Maturana, Ana Ricobaraza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-2009-1096"}], "href": "https://doi.org/10.3233/JAD-2009-1096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19542617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19542617"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Maria Genander, Michael M Halford, Nan-Jie Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2009.08.048"}], "href": "https://doi.org/10.1016/j.cell.2009.08.048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19914164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19914164"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Andrew C McClelland, Martin Hruska, Andrew J Coenen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0910644107"}], "href": "https://doi.org/10.1073/pnas.0910644107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20410461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20410461"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Katie E Foster, Julie Gordon, Kim Cardenas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB-ephrin-B2 interactions are required for thymus migration during organogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1003747107"}], "href": "https://doi.org/10.1073/pnas.1003747107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20616004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20616004"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Seth S Margolis, John Salogiannis, David M Lipton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2010.09.038"}], "href": "https://doi.org/10.1016/j.cell.2010.09.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21029865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21029865"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Alan E Lichtin "}, {"type": "b", "children": [{"type": "t", "text": "Clinical practice guidelines for the use of erythroid-stimulating agents: ASCO, EORTC, NCCN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Treat Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/978-1-4419-7073-2_14"}], "href": "https://doi.org/10.1007/978-1-4419-7073-2_14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21052960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21052960"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Alethia Villasenor, Diana C Chong, Mark Henkemeyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial dynamics of pancreatic branching morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.052993"}], "href": "https://doi.org/10.1242/dev.052993"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21098570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21098570"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Moustapha Cissé, Brian Halabisky, Julie Harris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reversing EphB2 depletion rescues cognitive functions in Alzheimer model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09635"}], "href": "https://doi.org/10.1038/nature09635"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21113149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21113149"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Benjamin K Attwood, Julie-Myrtille Bourgognon, Satyam Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropsin cleaves EphB2 in the amygdala to control anxiety."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09938"}], "href": "https://doi.org/10.1038/nature09938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21508957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21508957"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Sonal Thakar, George Chenaux, Mark Henkemeyer "}, {"type": "b", "children": [{"type": "t", "text": "Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1445"}], "href": "https://doi.org/10.1038/ncomms1445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21847105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21847105"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Costel C Darie, Katrin Deinhardt, Guoan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying transient protein-protein interactions in EphB2 signaling by blue native PAGE and mass spectrometry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.201000819"}], "href": "https://doi.org/10.1002/pmic.201000819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21932443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21932443"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Michael Benzinou, Frederic F Clermont, Tom G W Letteboer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1633"}], "href": "https://doi.org/10.1038/ncomms1633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22233626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22233626"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Stephen Tonna, Farzin M Takyar, Christina Vrahnas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.14-254300"}], "href": "https://doi.org/10.1096/fj.14-254300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24982128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24982128"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Mehdi Farshchian, Liisa Nissinen, Elina Siljamäki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2015.104"}], "href": "https://doi.org/10.1038/jid.2015.104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25789706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25789706"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Robert Nunan, Jessica Campbell, Ryoichi Mori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2015.09.085"}], "href": "https://doi.org/10.1016/j.celrep.2015.09.085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26549443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26549443"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Takashi Miyamoto, Daniel Kim, Joseph A Knox, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.666529"}], "href": "https://doi.org/10.1074/jbc.M115.666529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26589795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26589795"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Chand Parvez Danka Mohammed, Hwanseok Rhee, Bong-Kwan Phee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-204 downregulates EphB2 in aging mouse hippocampal neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.12444"}], "href": "https://doi.org/10.1111/acel.12444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26799631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26799631"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Ruo-Xi Zhang, Ying Han, Chen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychopharmacology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/npp.2016.58"}], "href": "https://doi.org/10.1038/npp.2016.58"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27103064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27103064"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Xiao-Dong Shi, Kai Sun, Rui Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1327-16.2016"}], "href": "https://doi.org/10.1523/JNEUROSCI.1327-16.2016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27881781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27881781"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Rui Hu, Pan Wei, Lu Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2017.140"}], "href": "https://doi.org/10.1038/cddis.2017.140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28358367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28358367"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Patrice N Mimche, Choon M Lee, Sylvie M Mimche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-20926-9"}], "href": "https://doi.org/10.1038/s41598-018-20926-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29416088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29416088"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Mariangela De Robertis, Tommaso Mazza, Caterina Fusilli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB2 stem-related and EphA2 progression-related miRNA-based networks in progressive stages of CRC evolution: clinical significance and potential miRNA drivers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-018-0912-z"}], "href": "https://doi.org/10.1186/s12943-018-0912-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30501625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30501625"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Anne-Sophie Ernst, Laura-Inés Böhler, Anna M Hagenston, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40478-019-0669-7"}], "href": "https://doi.org/10.1186/s40478-019-0669-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30722785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30722785"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Shinya Sato, Suhas Vasaikar, Adel Eskaros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.132447"}], "href": "https://doi.org/10.1172/jci.insight.132447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31661464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31661464"}]}]}]}