MIR4660 Gene

HGNC Family Non-coding RNAs
Name microRNA 4660
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts directly examine MIR4660, they collectively delineate the pivotal role of the protein phosphatase 1 (PP1) glycogen‐targeting subunit—encoded by PPP1R3A (also known as RGL or GM)—in the regulation of muscle glycogen metabolism. For example, studies using RGL knockout mice have shown that absence or reduction of PPP1R3A markedly diminishes both basal glycogen synthase activity and glycogen accumulation in skeletal muscle, without impairing insulin‐stimulated activation of glycogen synthase, thereby implicating its specific role in basal, rather than stimulus‐dependent, glycogen regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, alterations in PPP1R3A function have systemic metabolic repercussions. In cardiac tissue, for instance, changes in its network connectivity have been implicated in heart failure, suggesting that proper PP1 targeting by PPP1R3A is essential for maintaining metabolic homeostasis under stress conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In parallel, disruptions in glycogen handling due to PPP1R3A deficiency have been linked to obesity and insulin resistance, highlighting its influence on overall energy balance and glucose metabolism.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGiven the well‐established role of microRNAs in fine‐tuning gene expression, it is plausible to hypothesize that MIR4660 could act as a post‐transcriptional regulator within this metabolic framework. Although the abstracts focusing on glycogen metabolism"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "do not specifically mention MIR4660, related studies investigating microRNA regulatory roles in metabolic and stress‐response pathways provide context. For example, research on mesenchymal stromal cell extracellular vesicles, microRNA‐mediated regulation of oxalate synthesis, and testicular oxidative damage underscores the broad capacity of microRNAs to modulate cellular metabolism and stress responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": " Therefore, by extrapolation, MIR4660 may influence muscle and cardiac glycogen handling through the modulation of PPP1R3A expression or activity, ultimately contributing to energy homeostasis under physiological and pathophysiological conditions.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Suzuki, C Lanner, J H Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.21.8.2683-2694.2001"}], "href": "https://doi.org/10.1128/MCB.21.8.2683-2694.2001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11283248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11283248"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mirela Delibegovic, Christopher G Armstrong, Lorraine Dobbie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.52.3.596"}], "href": "https://doi.org/10.2337/diabetes.52.3.596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12606498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12606498"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David B Savage, Lanmin Zhai, Balasubramanian Ravikumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pmed.0050027"}], "href": "https://doi.org/10.1371/journal.pmed.0050027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18232732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18232732"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "James Paterson, Ian R Kelsall, Patricia T W Cohen "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/JME-07-0120"}], "href": "https://doi.org/10.1677/JME-07-0120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18234908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18234908"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Pablo Cordero, Victoria N Parikh, Elizabeth T Chin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-10591-5"}], "href": "https://doi.org/10.1038/s41467-019-10591-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31235787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31235787"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xin Tu, Yuanyuan Zhao, Qianqian Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human MiR-4660 regulates the expression of alanine-glyoxylate aminotransferase and may be a biomarker for idiopathic oxalosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Nephrol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10157-019-01723-8"}], "href": "https://doi.org/10.1007/s10157-019-01723-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30852714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30852714"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Meng-Meng Shi, Ying-Gang Zhu, Jia-Yang Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of miR-466 in mesenchymal stromal cell derived extracellular vesicles treating inoculation pneumonia caused by multidrug-resistant Pseudomonas aeruginosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ctm2.287"}], "href": "https://doi.org/10.1002/ctm2.287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33463070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33463070"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ziling Wang, Kunhang Du, Jiying Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13510002.2023.2206197"}], "href": "https://doi.org/10.1080/13510002.2023.2206197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37102430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37102430"}]}]}]}
NCBI Gene ID 100616350
API
Download Associations
Predicted Functions View MIR4660's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4660's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4660's ARCHS4 Predicted Functions.

Functional Associations

MIR4660 has 184 functional associations with biological entities spanning 4 categories (molecular profile, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4660 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4660 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4660 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4660 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4660 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4660 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR4660 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4660 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4660 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4660 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.