MIR4661 Gene

HGNC Family Non-coding RNAs
Name microRNA 4661
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have identified a specific member of the miR-4661 family—miR‑4661‑5p—as a promising serum exosomal biomarker for hepatocellular carcinoma (HCC). In an integrative analysis of RNA sequencing datasets, miR‑4661‑5p emerged as one of several oncogenic microRNAs, demonstrating outstanding diagnostic accuracy with an area under the receiver operating characteristic curve (AUROC) exceeding 0.9 even in early-stage HCC. These findings underscore its potential role in reflecting tumor biology and facilitating early, non‐invasive detection of HCC, possibly contributing to improved clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, another study has focused on the miR‑466 family in the context of bone health. Specifically, the investigation of miR‑466 l‑3p suggests that members of the miR‑466 family may be involved in regulating osteogenic differentiation processes, thereby influencing the development of osteoporosis. Although the precise mechanisms remain to be fully elucidated, these preliminary insights implicate miR‑466 in modulating pathways critical for bone formation and mineral homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hyo Jung Cho, Geum Ok Baek, Chul Won Seo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal microRNA-4661-5p-based serum panel as a potential diagnostic biomarker for early-stage hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.3230"}], "href": "https://doi.org/10.1002/cam4.3230"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32537885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32537885"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiang Zhang, Jin Xu "}, {"type": "b", "children": [{"type": "t", "text": "A novel miR-466l-3p/FGF23 axis promotes osteogenic differentiation of human bone marrow mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2024.117123"}], "href": "https://doi.org/10.1016/j.bone.2024.117123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38735373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38735373"}]}]}]}
NCBI Gene ID 100616245
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Predicted Functions View MIR4661's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4661's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4661's ARCHS4 Predicted Functions.

Functional Associations

MIR4661 has 205 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 7 datasets.

Click the + buttons to view associations for MIR4661 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4661 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4661 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4661 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4661 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4661 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4661 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4661 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.