{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA survey of the literature describing myriad LIF‐dependent signaling networks—from the regulation of embryonic stem cell self‐renewal and pluripotency, through neuroprotective and immunomodulatory mechanisms, to roles in tissue remodeling, bone homeostasis, and reproductive function—reveals a broad spectrum of cellular responses mediated by LIF and its downstream effectors (e.g., STAT3, Klf4, Nanog, and others). In these studies, LIF is shown to serve as a pivotal paracrine and autocrine factor that not only sustains the undifferentiated state of stem cells and orchestrates differentiation in specific lineages, but also modulates responses to injury and inflammation in diverse tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, despite the extensive characterization of LIF‐dependent pathways and the multiple cellular processes they regulate, none of these abstracts provide any evidence or explicit reference to the microRNA MIR4666B. In the absence of reported data connecting MIR4666B to LIF signaling or the diverse biological functions illustrated herein, its role remains undefined within these contexts. Further research will be required to determine whether MIR4666B interacts with, modulates, or is otherwise integrated into the LIF‐mediated networks or other related cellular pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "16"}, {"type": "fg_f", "ref": "36"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "27"}, {"type": "fg_f", "ref": "24"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "26"}, {"type": "fg_f", "ref": "33"}, {"type": "fg_f", "ref": "19"}, {"type": "fg_f", "ref": "21"}, {"type": "fg_f", "ref": "28"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "17"}, {"type": "fg_f", "ref": "22"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "37"}, {"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "38"}, {"type": "fg_f", "ref": "34"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "35"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "25"}, {"type": "fg_f", "ref": "18"}, {"type": "fg_f", "ref": "32"}, {"type": "fg_f", "ref": "29"}, {"type": "fg_f", "ref": "31"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "15"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Masahiro Oka, Kenichi Tagoku, Thomas L Russell, et al. 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