{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that MIR4668 plays distinct regulatory roles in different physiological contexts. In a study focused on hepatic lipid metabolism, the long non‐coding RNA uc.372 was shown to bind the primary transcript of MIR4668 (along with pri‐miR-195), thereby suppressing its maturation. This inhibition relieves MIR4668‐mediated suppression of downstream lipogenic genes—including ACC, FAS, SCD1, and CD36—resulting in enhanced lipogenesis and hepatic lipid accumulation observed in models of NAFLD (db/db mice, high‐fat diet–fed mice, and NAFLD patients)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate investigation into host responses to bacterial infection, MIR4668-5p was identified as one of three novel microRNAs upregulated in human lung epithelial cells following infection with Burkholderia pseudomallei. The increased expression of MIR4668-5p targets the 3′-untranslated region of ATG10, a key regulator of autophagy. This targeting leads to reduced ATG10 levels, suppresses autophagic clearance, and ultimately promotes the intracellular survival of the pathogen."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Guo, Weiwei Fang, Libo Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-03072-8"}], "href": "https://doi.org/10.1038/s41467-018-03072-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29426937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29426937"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qian Li, Yao Fang, Pan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Burkholderia pseudomallei survival in lung epithelial cells benefits from miRNA-mediated suppression of ATG10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2015.1058474"}], "href": "https://doi.org/10.1080/15548627.2015.1058474"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26151773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26151773"}]}]}]}