{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have begun to elucidate roles for miR-4669 in human disease. In a genetic association study of ischemic stroke, a particular single‐nucleotide polymorphism in the miR-4669 precursor (rs35196866) was significantly associated with increased susceptibility to the condition, suggesting that variations in miR-4669 may influence vascular pathology and potentially modulate cellular responses in ischemic injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, miR-4669 has emerged as an important factor in tumor aggressiveness and recurrence. Functional characterization in Hep3B cells demonstrated that overexpression of miR-4669 enhances cellular migration and confers resistance to sorafenib, concomitant with elevated sirtuin 1 levels and increased expression of a long noncoding RNA associated with microvascular invasion. Moreover, miR-4669 actively promotes the release of tumor-derived exosomes and glyceraldehyde 3-phosphate dehydrogenase (GAPDH), thereby fostering an immunosuppressive tumor microenvironment through the induction of M2 macrophage polarization. These multifaceted roles underscore the potential of miR-4669 both as a predictive biomarker for treatment response and as a target for interventions aimed at reducing post-transplant HCC recurrence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Seoung-Jin Hong, Su Kang Kim, Dong Hwan Yun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between MicroRNA-4669 Polymorphism and Ischemic Stroke in a Korean Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/7238319"}], "href": "https://doi.org/10.1155/2019/7238319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31781304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31781304"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Toshiaki Nakano, Chao-Long Chen, I-Hsuan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miR-4669 Enhances Tumor Aggressiveness and Generates an Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma: Its Clinical Value as a Predictive Biomarker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24097908"}], "href": "https://doi.org/10.3390/ijms24097908"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37175615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37175615"}]}]}]}