{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that hsa‐miR-4674 exhibits differential expression in distinct human pathologies. In patients with prostate cancer, elevated levels of miR-4674 have been observed in the metastatic form compared to non-metastatic disease, and its candidate target genes (including JUNB, KMT2A, and XPO6) suggest a potential role in promoting tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, investigations focused on tissue repair and angiogenesis following myocardial injury have demonstrated that miR-4674 is significantly downregulated in affected patients. Functionally, overexpression of this human-specific microRNA in endothelial cells markedly impairs key angiogenic processes such as proliferation, migration, network tube formation, and spheroid sprouting. Mechanistic studies indicate that miR-4674 exerts its influence by modulating VEGF-stimulated p38 MAPK signaling through direct targeting of interleukin 1 receptor-associated kinase 1 (Irak1) and Bicd cargo adaptor 2 (Bicd2), while its inhibition yields pro-angiogenic effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional research into inflammatory conditions such as psoriasis—where macrophage activation and mitochondrial dynamics have been highlighted as key factors—did not identify a role for miR-4674. Although the pathogenesis of psoriasis involves complex signaling cascades, miR-4674 was not implicated in these processes, suggesting that its regulatory functions may be limited to pathways involved in cancer metastasis and vascular remodeling rather than in broader inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "E N Knyazev, T R Samatov, K A Fomicheva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA hsa-miR-4674 in Hemolysis-Free Blood Plasma Is Associated with Distant Metastases of Prostatic Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bull Exp Biol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10517-016-3358-6"}], "href": "https://doi.org/10.1007/s10517-016-3358-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27265126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27265126"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Basak Icli, Hao Li, Daniel Pérez-Cremades, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4674 regulates angiogenesis in tissue injury by targeting p38K signaling in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00542.2019"}], "href": "https://doi.org/10.1152/ajpcell.00542.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31913696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31913696"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ahmed Alalaiwe, Chi-Yuan Chen, Zi-Yu Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms221910410"}], "href": "https://doi.org/10.3390/ijms221910410"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34638757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34638757"}]}]}]}