{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐4677-3p has emerged as an important regulatory molecule in several pathologic conditions, notably in cancer and fibrosis. In lung adenocarcinoma, for example, the long noncoding RNA TTN-AS1 is upregulated and directly binds to miR‐4677-3p, thereby suppressing its expression. Loss of miR‐4677-3p function leads to a de-repression of ZEB1, a transcription factor that drives epithelial-mesenchymal transition, promoting proliferation, migration, and invasion of cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLikewise, in glioma, the oncogenic lncRNA GLIDR sequesters miR‐4677-3p, which normally targets the membrane-associated scaffold protein MAGI2. This interaction abrogates miR‐4677-3p’s suppressive effect on MAGI2, facilitating increased cell proliferation and reduced apoptosis, and thereby contributing to glioma progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, miR‐4677-3p is markedly downregulated. Experimental overexpression of this microRNA significantly inhibits cancer cell proliferation, migration, and invasion through direct binding to the 3′ untranslated region of CEMIP. This binding downregulates CEMIP expression and attenuates its promotion of the PI3K/AKT signaling pathway, underscoring the tumor-suppressive role of miR‐4677-3p in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in the context of liver fibrosis, the circular RNA circ_0044226 functions as a molecular sponge by binding miR‐4677-3p. This sequestration reduces miR‐4677-3p availability, leading to elevated expression of SEC61G, decreased endoplasmic reticulum stress, and altered hepatic stellate cell activity. Conversely, knockdown of circ_0044226 releases miR‐4677-3p, thereby enhancing autophagy and apoptosis in hepatic stellate cells, and ultimately mitigating fibrotic progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuanbo Zhong, Jin Wang, Wen Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TTN-AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR-4677-3p/ZEB1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28973"}], "href": "https://doi.org/10.1002/jcb.28973"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31173403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31173403"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qi Yu, Xinxing Li, Tianda Feng "}, {"type": "b", "children": [{"type": "t", "text": "GLIDR promotes the progression of glioma by regulating the miR-4677-3p/MAGI2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2021.112726"}], "href": "https://doi.org/10.1016/j.yexcr.2021.112726"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34237299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34237299"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chen Mi, Dan Zhang, Yarui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4677-3p participates proliferation and metastases of gastric cancer cell via CEMIP-PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1971375"}], "href": "https://doi.org/10.1080/15384101.2021.1971375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34437815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34437815"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shanshan Yuan, Jiaming Liu, Li Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bioenerg Biomembr (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10863-024-10007-0"}], "href": "https://doi.org/10.1007/s10863-024-10007-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38421527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38421527"}]}]}]}