{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided abstracts center on the functions of CREB‐regulated transcription coactivators—most notably CRTC3—in diverse metabolic, thermogenic, and cellular stress pathways, none of them directly address or mention MIR4680. Several studies describe how CRTC3 modulates adipose tissue function by attenuating β‐adrenergic receptor signaling, thereby promoting obesity, as well as by regulating brown adipose tissue thermogenesis through downstream effectors such as Rgs2 and UCP1. Cold exposure and cAMP‐stimulated signaling induce the nuclear translocation of CRTC3, an event linked to the regulation of microRNAs (for example, miR‐206) that influence sympathetic outflow and energy expenditure."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations in the collection expand on the role of the CREB/CRTC axis in mitochondrial biogenesis and skeletal muscle remodeling. In models of catecholaminergic stress and mitochondrial inhibition, activation of CRTC coactivators (CRTC2/3) enhances PGC‐1α–dependent transcription that drives mitochondrial replication and supports anabolic adaptations after intense exercise. Moreover, cross talk between the CREB/CRTC pathway and other signal transduction systems—such as the JAK/STAT and AMPK/MARK cascades—further underscores the broad impact of these coactivators on key cellular decisions and energy balance, including effects in hematopoietic stem cell survival and adipogenic transformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional work has revealed roles for CRTC3 in distinct processes such as melanogenesis and even in the regulation of social dominance via astrocyte‐derived growth factors. Collectively these studies illustrate how the CREB/CRTC signaling network orchestrates multiple transcriptional programs across various tissues. However, despite the extensive insights provided into the roles and regulatory mechanisms of CRTC3 and its associated pathways, the function of MIR4680 was not explored or mentioned in any of these reports. Future research will be needed to characterize the potential involvement of MIR4680 within these complex regulatory circuits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Youngsup Song, Judith Altarejos, Mark O Goodarzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRTC3 links catecholamine signalling to energy balance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09564"}], "href": "https://doi.org/10.1038/nature09564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21164481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21164481"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tizhong Shan, Yan Xiong, Pengpeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12205"}], "href": "https://doi.org/10.1038/ncomms12205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27461402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27461402"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Young-Sil Yoon, Wen-Wei Tsai, Sam Van de Velde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1805257115"}], "href": "https://doi.org/10.1073/pnas.1805257115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29784793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29784793"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ziye Xu, Jiaqi Liu, Wenjing You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold exposure induces nuclear translocation of CRTC3 in brown adipose tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28189"}], "href": "https://doi.org/10.1002/jcb.28189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30506739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30506739"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tin Aung Than, Huan Lou, Cheng Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.240481"}], "href": "https://doi.org/10.1074/jbc.M111.240481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21536665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21536665"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nelson E Bruno, Kimberly A Kelly, Richard Hawkins, et al. 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