{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch into autoimmune diseases has highlighted the importance of circular RNAs, as exemplified by circPTPN22’s involvement in conditions such as systemic lupus erythematosus and rheumatoid arthritis. However, within this context, no functional link to miR-4689 was delineated, leaving its role largely unexplored in autoimmune disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, studies of pancreatic cancer have uncovered a critical oncogenic pathway in which the hypoxia‐induced long non-coding RNA LINC00460 plays a pivotal role. LINC00460 functions as a molecular sponge for miR-4689, thereby attenuating miR-4689’s ability to downregulate its downstream target UBE2V1. The consequent upregulation of UBE2V1 leads to enhanced stability of mutant p53, a well-known promoter of tumor progression. Moreover, by sequestering USP10—a deubiquitinase that would normally regulate p53 turnover—LINC00460 further reinforces mutant p53 stabilization and fuels pancreatic tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhuyan Jiang, Shifei Li, Yuying Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13075-023-03150-3"}], "href": "https://doi.org/10.1186/s13075-023-03150-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37858140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37858140"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ronghao Zhang, Xinjing Wang, Xiayang Ying, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.87833"}], "href": "https://doi.org/10.7150/ijms.87833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37786443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37786443"}]}]}]}