{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent genome‐wide association studies have implicated MIR4697 as a genetic locus modulating Parkinson’s disease (PD) risk. Several independent studies in Taiwanese, Iranian, and Han Chinese cohorts found that the single nucleotide polymorphism (SNP) rs329648 within MIR4697 is significantly associated with PD. In one study, a recessive model indicated that the TT genotype of rs329648 was marginally protective against PD, whereas other analyses reported that the T allele occurred more frequently among PD patients—particularly in male subjects—supporting its role in PD susceptibility and suggesting ethnic‐ and sex‐dependent effects. These observations are further driving investigations into the mechanistic links through which MIR4697 may contribute to PD pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its involvement in neurodegenerative disease, MIR4697 also plays a functional role in ovarian cancer. Recent findings have demonstrated that hsa‐miR‐4697-3p is a key component of a competing endogenous RNA (ceRNA) network involving MNX1-AS1 and HOXB13. This network appears to modulate chemotherapy response by influencing drug metabolism and neural signaling pathways, thereby affecting platinum sensitivity. These insights not only expand the biological context in which MIR4697 operates but also highlight its potential as a therapeutic target for overcoming chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies underscore MIR4697 as a multifaceted regulator that impacts both genetic risk in Parkinson’s disease and therapeutic response in ovarian cancer. Further functional analyses are warranted to elucidate the molecular mechanisms underlying MIR4697’s contributions to neurodegeneration and tumor chemosensitivity, which may ultimately pave the way for improved biomarker development and targeted therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chiung-Mei Chen, Yi-Chun Chen, Mu-Chun Chiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2015.12.016"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2015.12.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26804608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26804608"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tannaz Safaralizadeh, Javad Jamshidi, Ehsan Esmaili Shandiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SIPA1L2, MIR4697, GCH1 and VPS13C loci and risk of Parkinson's diseases in Iranian population: A case-control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jns.2016.08.001"}], "href": "https://doi.org/10.1016/j.jns.2016.08.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27653855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27653855"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xinglong Yang, Jinhua Zheng, Ran An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphism in MIR4697 but not VPS13C, GCH1, or SIPA1L2 is associated with risk of Parkinson's disease in a Han Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2017.04.003"}], "href": "https://doi.org/10.1016/j.neulet.2017.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28380328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28380328"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Myungsik Yoo, Klaudia Bunkowski, Andrew Lie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of MicroRNA-4697-3p by Parkinson's disease-associated SNP rs329648 and its impact on SNCA112 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-024-09725-w"}], "href": "https://doi.org/10.1007/s11033-024-09725-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39001947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39001947"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Anqi Wu, Jiaqi Liu, Xiaojun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive network analysis of dysregulated genes revealed MNX1-AS1/hsa-miR-4697-3p/HOXB13 axis in ovarian cancer chemotherapy response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15447"}], "href": "https://doi.org/10.1111/cas.15447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35639251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35639251"}]}]}]}