MIR4701 Gene

HGNC Family Non-coding RNAs
Name microRNA 4701
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that miR-4701-5p plays a critical role in modulating cellular behavior through its ability to regulate key glycosylation enzymes. In chronic myeloid leukemia, miR-4701-5p directly targets the sialyltransferase ST3GAL1, thereby reducing the aberrant sialylation profile associated with multidrug resistance. This targeting not only decreases chemoresistance in vitro but also converts adriamycin‐resistant tumor cells to a more susceptible phenotype in vivo, suggesting a promising therapeutic avenue for overcoming drug resistance in leukemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, miR-4701-5p has emerged as an important regulator in the pathogenesis of joint diseases such as osteoarthritis. Its involvement in processes like synovial invasion and joint destruction highlights miR-4701-5p’s potential impact on cartilage integrity and inflammatory joint remodeling, thereby offering novel insights into therapeutic strategies for mitigating joint damage in osteoarthritis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Li, Shihua Luo, Weijie Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2016.50"}], "href": "https://doi.org/10.1038/labinvest.2016.50"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27088512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27088512"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hui Zhang, Cheng Chen, Jie Song "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-4701-5p protects against interleukin-1β induced human chondrocyte CHON-001 cells injury via modulating HMGA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Surg Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13018-022-03083-8"}], "href": "https://doi.org/10.1186/s13018-022-03083-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35459188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35459188"}]}]}]}
NCBI Gene ID 100616262
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Predicted Functions View MIR4701's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4701's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4701's ARCHS4 Predicted Functions.

Functional Associations

MIR4701 has 342 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4701 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4701 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4701 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4701 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4701 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4701 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4701 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR4701 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4701 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4701 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.