| HGNC Family | Non-coding RNAs |
| Name | microRNA 4707 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA MIR4707 has emerged as an important regulatory molecule involved in distinct biological processes by acting through different molecular mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the cardiovascular system, the microRNA isoform miR-4707-5p is normally implicated in promoting apoptosis in vascular endothelial cells. However, its activity is counteracted by a novel long non-coding RNA (lncRNA), LOC100129973, which functions as a molecular sponge. By sequestering miR-4707-5p (as well as miR-4767), this lncRNA upregulates key anti-apoptotic regulators—namely, Apoptosis Inhibitor 5 (API5) and BCL2 like 12 (BCL2L12)—thereby mitigating apoptosis induced by serum and FGF-2 starvation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of neurodevelopment, a distinct isoform, miR-4707-3p, plays a crucial role in brain formation. Expression quantitative trait loci (eQTL) analyses in mid-gestation human neocortical tissue have linked variations in miR-4707-3p expression to differences in educational attainment and brain size phenotypes. Functionally, exogenous expression of miR-4707-3p in primary human neural progenitor cells leads to the downregulation of its predicted targets and an increase in cell proliferation, highlighting its role in modulating gene regulation and cell fate decisions during neocortical development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Lu, Shu Ya Huang, Le Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep21620"}], "href": "https://doi.org/10.1038/srep21620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26887505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26887505"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael J Lafferty, Nil Aygün, Niyanta K Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.79488"}], "href": "https://doi.org/10.7554/eLife.79488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36629315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36629315"}]}]}]}
|
| Synonyms | MIR-4707 |
| NCBI Gene ID | 100616424 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR4707 has 1,445 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.
Click the + buttons to view associations for MIR4707 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR4707 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4707 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MIR4707 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR4707 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR4707 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4707 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR4707 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MIR4707 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MIR4707 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR4707 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR4707 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR4707 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR4707 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |