MIR4710 Gene

HGNC Family Non-coding RNAs
Name microRNA 4710
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a study focused on peripheral B cell survival and autoantigen tolerance, researchers identified EndoU—an ancient single‐stranded RNA‐binding protein—as a key regulator controlling activation-induced cell death and c-Myc expression in B cells. Although this work underscores the importance of RNA-dependent regulatory pathways in immune function, it does not specifically address or provide a functional role for MIR4710."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate study examining the diagnostic potential of circulating microRNAs in breast cancer—particularly regarding axillary lymph node metastasis—the promising role of miRNAs as biomarkers is highlighted. However, similar to the first report, this study does not delineate a role for individual miRNAs such as MIR4710, leaving its specific function in the context of cancer progression and metastasis undetermined."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jonathan C Poe, Evgueni I Kountikov, Jacquelyn M Lykken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EndoU is a novel regulator of AICD during peripheral B cell selection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20130648"}], "href": "https://doi.org/10.1084/jem.20130648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24344237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24344237"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bin Yang, Ya-Wen Wang, Lin-Hui Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulated miR-367-3p, miR-548aq-5p, and miR-4710 in Human Whole Blood: Potential Biomarkers for Breast Cancer With Axillary Lymph Node Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Breast Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clbc.2022.11.011"}], "href": "https://doi.org/10.1016/j.clbc.2022.11.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36564279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36564279"}]}]}]}
Synonyms MIR-4710
NCBI Gene ID 100616300
API
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Predicted Functions View MIR4710's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4710's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4710's ARCHS4 Predicted Functions.

Functional Associations

MIR4710 has 836 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4710 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4710 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4710 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR4710 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4710 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4710 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4710 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4710 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4710 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4710 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.