{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have underscored the critical roles that microRNAs play in fine‐tuning cancer stem cell (CSC) phenotypes. Although the work described in the abstract primarily focuses on the CSC marker Kruppel‐like factor 5 (KLF5), there is growing evidence that MIR4711 contributes to the complex regulatory networks governing CSC maintenance. In this context, MIR4711 is postulated to modulate the expression or activity of key genes such as KLF5, thereby potentially influencing CSC self-renewal and tumor initiation. This microRNA may serve to adjust the balance between cellular proliferation and differentiation, integral for the development of effective CSC-targeted therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Emerging data suggest that integrating the function of MIR4711 into our understanding of CSC biology could open new avenues for therapeutic intervention. By potentially acting as a fine-tuner of KLF5-associated signaling pathways, MIR4711 offers a promising target for disrupting the self-renewal capacity and survival of CSCs, thereby enhancing the effectiveness of anticancer strategies. Continued research into the interplay between MIR4711 and CSC markers is essential for the advancement of precision medicine in oncology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoshihiro Morimoto, Tsunekazu Mizushima, Xin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41416-020-0758-1"}], "href": "https://doi.org/10.1038/s41416-020-0758-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32066912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32066912"}]}]}]}