{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a recent study on childhood obesity, the role of neuropeptides and their regulatory mechanisms was investigated, leading to the identification of miR-4713 as a potential contributor to the condition. In adipose tissue samples obtained from children with obesity, miR-4713 was found to be significantly downregulated compared to non‐obese controls, suggesting that its reduced expression may influence the dysregulation of neuropeptide signaling that is characteristic of obesity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe study constructed a regulatory network centered around the neuropeptide receptor NPY1R, in which transcription factors, including TCF4 and HEY1, were shown to positively correlate with NPY1R expression through their influence on miR-4713. In contrast, the transcription factor GATA3 demonstrated an inverse relationship by affecting miR-452. The coordinated regulation via these pathways emphasizes the role of miR-4713 in modulating the expression of key regulatory genes within the network, potentially impacting downstream effects associated with obesity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinically, the reduced levels of miR-4713, along with altered expression of related transcription factors and miR-452, suggest that miR-4713 may serve as an important risk factor, not only for the development of obesity but also for increased fracture susceptibility in obese children. These findings provide new insights into the molecular mechanisms underlying childhood obesity and associated complications, and highlight miR-4713 as a potential target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoyan Feng, Ye Ding, Min Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NPY1R"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " for the Prevention of Childhood Obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/2843353"}], "href": "https://doi.org/10.1155/2022/2843353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35401881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35401881"}]}]}]}