{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have highlighted the role of miR-4715-3p in cancer cell regulation. In upper gastrointestinal adenocarcinomas, miR-4715-3p directly binds to the 3′ untranslated region of Aurora kinase A (AURKA) mRNA, resulting in downregulation of AURKA expression. This reduction impedes proper progression through the G2/M phase and promotes chromosomal abnormalities, leading to cell cycle arrest and eventual cell death. Furthermore, the decrease in AURKA is accompanied by diminished levels of the ferroptosis inhibitor GPX4 and elevated apoptotic signals, suggesting that miR-4715-3p restoration or AURKA inhibition may trigger both apoptotic and ferroptotic pathways. Epigenetic modifications, such as increased methylation upstream of the miR-4715-3p gene, contribute to its silencing and further aggravate oncogenic progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in carcinogenesis, miR-4715-3p has also been implicated in the progression of nonalcoholic fatty liver disease (NAFLD). Transcriptomic analyses have revealed a correlation between miR-4715-3p and the expression of Gasdermin D (GSDMD), a protein associated with macrophage infiltration and the development of fibrosis in NAFLD. This miR-4715-3p/GSDMD axis appears to modulate macrophage-associated immune responses, suggesting that it may serve both as a biomarker for disease progression and as a potential therapeutic target for mitigating liver fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ahmed Gomaa, Dunfa Peng, Zheng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-53174-6"}], "href": "https://doi.org/10.1038/s41598-019-53174-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31740746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31740746"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuai Chen, Xiurong Cai, Yu Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The macrophage-associated microRNA-4715-3p / Gasdermin D axis potentially indicates fibrosis progression in nonalcoholic fatty liver disease: evidence from transcriptome and biological data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2072602"}], "href": "https://doi.org/10.1080/21655979.2022.2072602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35521691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35521691"}]}]}]}