MIR4718 Gene

HGNC Family Non-coding RNAs
Name microRNA 4718
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe recent study investigating regulatory T (Treg) cell polarization (PubMed:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "details an epigenetic pathway wherein the H3K4 methyltransferase Ash1l upregulates Smad3 transcription during TGF‑β–mediated Treg cell differentiation, with counter‐regulation provided by the long noncoding RNA lnc‑Smad3. However, in this work, no direct mention or functional characterization of MIR4718 was provided, leaving its potential role in modulating Treg cell fate or related epigenetic processes unaddressed.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, a separate investigation aimed at identifying biomarkers for cisplatin-induced nephrotoxicity (PubMed:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "does not include any information about MIR4718. The absence of data on MIR4718 in the context of cisplatin treatment suggests that its function was not examined as a potential predictive biomarker for renal toxicity in this study.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, although both articles contribute valuable insights into distinct biomedical mechanisms—one elucidating epigenetic control in immune regulation and the other addressing the unmet need for nephrotoxicity biomarkers—neither provides evidence regarding the function of MIR4718. Additional targeted research will be required to determine whether MIR4718 plays a regulatory role in Treg cell biology, cancer therapy outcomes, or other related biological processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meng Xia, Juan Liu, Shuxun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms15818"}], "href": "https://doi.org/10.1038/ncomms15818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28598443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28598443"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Julia C F Quintanilha, Maria A Cursino, Jessica B Borges, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-021-08317-2"}], "href": "https://doi.org/10.1186/s12885-021-08317-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34011306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34011306"}]}]}]}
NCBI Gene ID 100616195
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Predicted Functions View MIR4718's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4718's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4718's ARCHS4 Predicted Functions.

Functional Associations

MIR4718 has 191 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for MIR4718 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4718 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4718 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4718 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4718 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4718 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4718 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4718 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4718 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.