{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn glioblastoma multiforme cells, miR‑4725‑3p functions as a critical inhibitor of cellular invasion. Its expression is up-regulated following treatment with xanthohumol—a prenylated flavonoid derived from hops—which in turn leads to the direct targeting and suppression of STIM1 by binding to its 3′‑untranslated region. As STIM1 is known to promote glioma cell invasion, its inhibition by miR‑4725‑3p effectively attenuates pro‑invasive signaling and may disrupt pathways such as the epithelial-to-mesenchymal transition that are otherwise activated in aggressive tumor phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, the study indicates that the up-regulation of miR‑4725‑3p is at least partially mediated by the extracellular signal‑regulated kinase/c‑Fos pathway, revealing a novel mechanistic link between xanthohumol treatment and the suppression of glioma malignancy. These insights underscore the therapeutic potential of modulating miR‑4725‑3p levels as a means to restrain STIM1‑dependent invasion in glioblastoma and pave the way for the development of targeted interventions against this deadly brain tumor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kuo-Hao Ho, Cheng-Kuei Chang, Peng-Hsu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4725-3p targeting stromal interacting molecule 1 signaling is involved in xanthohumol inhibition of glioma cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.14459"}], "href": "https://doi.org/10.1111/jnc.14459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29747239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29747239"}]}]}]}