{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have highlighted the potential of miR‐4730 as a diagnostic and prognostic biomarker in pancreatic cancer. In this context, screening efforts have focused on identifying differentially expressed microRNAs, with miR‐4730 emerging as a candidate marker whose expression profile may provide insights into early detection and clinical outcomes in one of the most aggressive gastrointestinal tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn liver cancer, miR‐4730 has been shown to act as a tumor suppressor. Studies revealed that its expression is significantly suppressed in tumor tissues and cell lines. Functionally, overexpression of miR‐4730 inhibited cell proliferation, impeded cell cycle progression, and promoted apoptosis. Mechanistic analyses demonstrated that miR‐4730 directly targets high mobility group A1 (HMGA1), leading to the inhibition of the integrin-linked kinase (ILK)/Akt/glycogen synthase kinase‑3β (GSK3β) pathway. Notably, lower miR‐4730 expression levels were associated with poorer recurrence-free survival, underscoring its potential utility both as a prognostic marker and as a therapeutic target in liver cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "W Yang, H-Y Ju, X-F Tian "}, {"type": "b", "children": [{"type": "t", "text": "Hsa-miR-4730 as a new and potential diagnostic and prognostic indicators for pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202009_22819"}], "href": "https://doi.org/10.26355/eurrev_202009_22819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32964968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32964968"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hirotaka Furuke, Hirotaka Konishi, Tomohiro Arita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑4730 suppresses the progression of liver cancer by targeting the high mobility group A1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2022.5139"}], "href": "https://doi.org/10.3892/ijmm.2022.5139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35485281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35485281"}]}]}]}