MIR4731 Gene

HGNC Family Non-coding RNAs
Name microRNA 4731
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐4731 exerts crucial regulatory functions in central nervous system tumors and melanoma. In glioblastoma, ectopic expression of miR‐4731 via AD‐MSC delivery inhibited cell proliferation, induced cell cycle arrest, and promoted apoptosis, indicating its tumor‐suppressive role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, in glioma cells, upregulated FLVCR1‑AS1 sequestered miR‐4731‑5p, thereby de‐repressing E2F2 expression and facilitating malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in melanoma, miR‐4731–5p was found enriched and functionally downregulated several cell cycle and melanosome‐associated genes, including members of the SSX family, resulting in reduced colony formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumor biology, miR‐4731 also participates in the regulation of cardiovascular and fibrotic processes. In vascular smooth muscle cells, binding of miR‐4731‑5p by the cytoplasmic lncRNA SENCR and its modulation by FOXO3a contributes to the inhibition of proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in models of cardiac hypertrophy, miR‐4731 is targeted by endothelial progenitor cell–derived exosomal circ_0018553; overexpression of miR‐4731 in cardiomyocytes enhanced hypertrophic responses through repression of SIRT2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In the context of ligamentum flavum hypertrophy associated with lumbar spinal stenosis, the circPDK1/miR‐4731‑5p/TNXB axis was shown to promote cell proliferation and fibrosis, highlighting a regulatory axis critical in tissue remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn additional malignancies, miR‐4731 functions within competing endogenous RNA networks to affect therapeutic response and progression. In renal cell carcinoma, the circular RNA circEHD2 sponges miR‐4731‑5p, which in turn modulates ABCF2 expression and enhances sunitinib resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In gastric cancer, upregulation of LINC01857 reduces miR‐4731‑5p availability, thereby increasing HOXC6 expression and promoting oncogenic behaviors such as proliferation, migration, invasion, and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amir Allahverdi, Ehsan Arefian, Masoud Soleimani, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA FLVCR1-AS1 aggravates biological behaviors of glioma cells via targeting miR-4731-5p/E2F2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.10.106"}], "href": "https://doi.org/10.1016/j.bbrc.2019.10.106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31699367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31699367"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mitchell S Stark, Lisa N Tom, Glen M Boyle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The \"melanoma-enriched\" microRNA miR-4731-5p acts as a tumour suppressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10109"}], "href": "https://doi.org/10.18632/oncotarget.10109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27331623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27331623"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Famin Ye, Jing Zhang, Qiaoling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary study on the mechanism of long noncoding RNA SENCR regulating the proliferation and migration of vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29775"}], "href": "https://doi.org/10.1002/jcp.29775"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32401347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32401347"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Huihua Zuo, Liang Li, Xiaoqing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel circ_0018553 protects against angiotensin-induced cardiac hypertrophy in cardiomyocytes by modulating the miR-4731/SIRT2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertens Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41440-022-01111-y"}], "href": "https://doi.org/10.1038/s41440-022-01111-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36474029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36474029"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kai Zhang, Xin Wang, Li-Ting Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA PDK1 targets miR-4731-5p to enhance TNXB expression in ligamentum flavum hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202200022RR"}], "href": "https://doi.org/10.1096/fj.202200022RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37014317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37014317"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wen Li, GaiXia Li, LuQuan Cao "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA Eps15-homology domain-containing protein 2 induce resistance of renal cell carcinoma to sunitinib via microRNA-4731-5p/ABCF2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2059960"}], "href": "https://doi.org/10.1080/21655979.2022.2059960"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35412955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35412955"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shudong Chen, Jundi Dai, Wei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01857 promotes the proliferation, migration, and invasion of gastric cancer cells via regulating miR-4731-5p/HOXC6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Can J Physiol Pharmacol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/cjpp-2021-0411"}], "href": "https://doi.org/10.1139/cjpp-2021-0411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35468304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35468304"}]}]}]}
NCBI Gene ID 100616125
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Predicted Functions View MIR4731's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4731's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4731's ARCHS4 Predicted Functions.

Functional Associations

MIR4731 has 210 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for MIR4731 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4731 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4731 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4731 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4731 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4731 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4731 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4731 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4731 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.