MIR4735 Gene

HGNC Family Non-coding RNAs
Name microRNA 4735
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA-4735-3p emerges as a multifaceted regulator involved in diverse pathological conditions. In clear cell renal cell carcinoma, it is being investigated for its potential role in modulating ferroptosis, a form of regulated cell death implicated in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In bladder cancer, miR-4735-3p functions as a tumor suppressor by targeting oncogenic pathways; it is sequestered by the long non-coding RNA ARAP1-AS1, which diminishes its ability to downregulate NOTCH2, thereby contributing to malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, in non-small cell lung cancer, miR-4735-3p is found to be upregulated and plays an oncogenic role. It negatively regulates FBXL3, a protein that otherwise suppresses cell proliferation and invasion. Functional rescue assays have confirmed that the tumor-promoting effects of miR-4735-3p can be counteracted by FBXL3, highlighting its potential as a therapeutic target in this aggressive lung cancer subtype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, in the context of intracranial aneurysm, miR-4735 modulates the phenotype of vascular smooth muscle cells. By targeting the 3′-untranslated region of HIF-1, miR-4735 overexpression leads to reduced HIF-1 levels, which in turn impairs autophagy-induced proliferation and migration of these cells. This regulatory mechanism underscores the protective role of miR-4735 in preventing aberrant vascular remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cairong Zhu, Zhiquan Song, Zhen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anal Cell Pathol (Amst) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/4213401"}], "href": "https://doi.org/10.1155/2022/4213401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35646516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35646516"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jingfei Teng, Xing Ai, Zhuomin Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ARAP1-AS1 promotes the progression of bladder cancer by regulating miR-4735-3p/NOTCH2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2018.1538613"}], "href": "https://doi.org/10.1080/15384047.2018.1538613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30404578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30404578"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dazhong Wang, Xin Han, Chan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FBXL3 is regulated by miRNA-4735-3p and suppresses cell proliferation and migration in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2018.12.008"}], "href": "https://doi.org/10.1016/j.prp.2018.12.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30594330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30594330"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ge Gao, Yang Zhang, Yingjiu Chao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4735-3p regulates phenotypic modulation of vascular smooth muscle cells by targeting HIF-1-mediated autophagy in intracranial aneurysm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29219"}], "href": "https://doi.org/10.1002/jcb.29219"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31498485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31498485"}]}]}]}
NCBI Gene ID 100616363
API
Download Associations
Predicted Functions View MIR4735's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4735's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4735's ARCHS4 Predicted Functions.

Functional Associations

MIR4735 has 168 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 7 datasets.

Click the + buttons to view associations for MIR4735 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4735 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4735 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4735 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4735 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4735 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4735 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4735 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.