{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into osteoarthritis have identified miR-4738-3p as a key regulatory molecule that modulates the expression of the collagen type I alpha 2 chain (COL1A2), a hub gene implicated in the pathogenesis of OA. Through weighted gene co‐expression network analysis of the GSE55235 dataset and cellular assays, the study demonstrated that miR-4738-3p acts as a downstream target of COL1A2, influencing inflammatory cascades mediated by interleukin 1β and the NF-κB signaling pathway. This regulatory interplay helps to counteract inflammation and apoptosis, thereby contributing to cell survival in affected chondrocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, the research highlighted the significance of exosome-associated miR-4738-3p in intercellular communication. Enhanced levels of exosomal miR-4738-3p were shown to antagonize IL-1β-induced inflammatory responses and cell damage, while reduced levels exacerbated these detrimental effects, underscoring the microRNA’s therapeutic potential in OA management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Xu, Kaifeng Zhou, Huijie Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome miR-4738-3p-mediated regulation of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "COL1A2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " through the NF-κB and inflammation signaling pathway alleviates osteoarthritis low-grade inflammation symptoms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomol Biomed (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17305/bb.2023.9921"}], "href": "https://doi.org/10.17305/bb.2023.9921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38059912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38059912"}]}]}]}