MIR4743 Gene

HGNC Family Non-coding RNAs
Name microRNA 4743
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a study investigating major depressive disorder (MDD), miR‐4743 was identified among a panel of five microRNAs that were significantly up‐regulated in peripheral blood mononuclear cells of MDD patients. Functional annotation of its predicted target genes revealed enrichment in pathways associated with nervous system and brain functions, suggesting that miR‐4743 may contribute to the complex molecular mechanisms underlying MDD pathogenesis and holds promise as a blood‐based diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Notably, the concept of using circulating microRNAs as molecular markers is not confined to psychiatric disorders. In related research on type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD), investigators are exploring specific miRNA signatures as potential biomarkers of diabetic atherosclerosis, highlighting the broader role for microRNAs in regulating diverse cardiometabolic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Overall, the differential expression and potential regulatory functions of miR‐4743 in MDD, together with the expanding application of circulating miRNA profiles in other disease contexts, underscore the promise of miRNA‐based biomarkers for improving the diagnostic accuracy and our understanding of the molecular bases of complex disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui-min Fan, Xin-yang Sun, Wei Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatr Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jpsychires.2014.08.007"}], "href": "https://doi.org/10.1016/j.jpsychires.2014.08.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25201637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25201637"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Joanna Szydełko, Marcin Czop, Alicja Petniak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of plasma miR-4505, miR-4743-5p and miR-4750-3p as novel diagnostic biomarkers for coronary artery disease in patients with type 2 diabetes mellitus: a case-control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Diabetol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12933-024-02374-0"}], "href": "https://doi.org/10.1186/s12933-024-02374-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39080630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39080630"}]}]}]}
NCBI Gene ID 100616366
API
Download Associations
Predicted Functions View MIR4743's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4743's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4743's ARCHS4 Predicted Functions.

Functional Associations

MIR4743 has 482 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4743 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4743 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4743 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4743 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4743 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4743 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4743 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR4743 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4743 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4743 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.