{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of these abstracts provides an extensive view of the critical roles played by members of the Celsr family—especially Celsr2 and Celsr3—in neural development. In these studies, Celsr proteins are shown to regulate key developmental processes such as ciliogenesis, planar cell polarity, and the directional growth and guidance of axons. For instance, one study demonstrates that loss of Celsr2 compromises the formation and organizations of ependymal cilia, leading to disturbed cerebrospinal fluid dynamics and hydrocephalus, while others reveal that Celsr3 is indispensable for establishing major axonal tracts in the central nervous system."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther reports in the collection focus on how Celsr3 and its interacting partners, such as Frizzled3 and Vangl2, orchestrate neuronal migration, guidepost scaffold formation, and synapse development in diverse regions including the hippocampus, neocortex, the enteric nervous system, and even peripheral sensory circuits. These studies detail that disruptions in Celsr3 function can lead to profound alterations in axonal pathfinding, interneuron positioning, synaptic connectivity, and ultimately impair cognitive and motor functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther facets of Celsr3 function are further highlighted in studies addressing its impact on corticofugal and subcortical connections. Deficiencies in Celsr3 not only disrupt corticospinal and rubrospinal tracts but also compromise the maturation of spinal circuits, basal ganglia connectivity, and even the fine mapping of sensory projections in the dorsal root ganglia. These alterations are associated with changes in dendritic architecture, synaptic density, and motor as well as sensory behaviors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that throughout these studies the focus is entirely on the functions of Celsr family proteins and the planar cell polarity pathway in neural wiring, and there is no mention or evidence describing any role for MIR4752. Thus, while the abstracts provide rich insights into the molecular mechanisms governing neural development and connectivity via Celsr2, Celsr3, and their partners, they do not address any function of MIR4752.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fadel Tissir, Yibo Qu, Mireille Montcouquiol, et al. 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