{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that members of the MIR4756 family play versatile roles in regulating gene expression in distinct disease contexts. In one study examining Huntington's disease, hsa-miR-4756-5p was shown to directly interact with the huntingtin (HTT) gene's 3'-UTR. This interaction significantly reduced reporter activity and lowered endogenous HTT protein levels, suggesting that this miRNA may serve as an endogenous regulator of HTT expression and a potential target for therapeutic strategies aimed at reducing toxic gain-of-function in HD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate investigation focused on triple negative breast cancer (TNBC), hsa-miR-4756-3p was identified as a master regulator influencing several key cellular processes. It modulated apoptosis, proliferation, migration, and the cell cycle, primarily by targeting forkhead box protein M1 (FOXM1). The suppression of FOXM1 disrupted downstream TGF‑β1 signalling and epithelial–mesenchymal transition (EMT), collectively contributing to reduced tumour growth and metastatic potential in TNBC models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kyung-Hee Kim, Kawther Abu Elneel, Jun Wan Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Full sequence of mutant huntingtin 3'-untranslated region and modulation of its gene regulatory activity by endogenous microRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-019-0639-8"}], "href": "https://doi.org/10.1038/s10038-019-0639-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31296921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31296921"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuanliang Gu, Wenjuan Wang, Xuyao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated network analysis identifies hsa-miR-4756-3p as a regulator of FOXM1 in Triple Negative Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-50248-3"}], "href": "https://doi.org/10.1038/s41598-019-50248-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31554904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31554904"}]}]}]}