{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations in breast cancer have revealed that miR‑4766‑5p functions as a potent tumor suppressor. Specifically, in human breast cancer tissues and cell lines, upregulation of lncRNA‑PRLB was found to inhibit miR‑4766‑5p, thereby releasing its repression on the target gene SIRT1. This cascade promotes cell proliferation, metastasis, and chemoresistance, ultimately correlating with aggressive disease and poorer patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn esophageal squamous cell carcinoma (ESCC), a different regulatory mechanism involving miR‑4766‑5p was observed. The circular RNA circPDE3B acts as a competing endogenous RNA (ceRNA) by sponging miR‑4766‑5p, which normally suppresses the expression of laminin α1 (LAMA1). The sequestration of miR‑4766‑5p thereby permits LAMA1 overexpression, promoting tumorigenesis, cell migration, and invasion through the induction of epithelial‑mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided study on lung adenocarcinoma did not specifically address miR‑4766‑5p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", the combined findings from breast cancer and ESCC underscore the critical role of miR‑4766‑5p in modulating oncogenic pathways. Its suppression—either through sequestration by long non‑coding or circular RNAs—appears to contribute significantly to cancer progression. This highlights the therapeutic potential of strategies aimed at restoring or mimicking miR‑4766‑5p function across multiple malignancies.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yiran Liang, Xiaojin Song, Yaming Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0582-1"}], "href": "https://doi.org/10.1038/s41419-018-0582-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29752439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29752439"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peng Li Zhou, Zhengyang Wu, Wenguang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03911-5"}], "href": "https://doi.org/10.1038/s41419-021-03911-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34226522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34226522"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hong Wang, Dongsheng He "}, {"type": "b", "children": [{"type": "t", "text": "LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-610"}], "href": "https://doi.org/10.14670/HH-18-610"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36994814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36994814"}]}]}]}