{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch in vascular endothelial cells has revealed that miR‑4767 functions as a pro‑apoptotic microRNA whose activity is counteracted by its sequestration within the novel long non‑coding RNA (lncRNA) LOC100129973. By “sponging” miR‑4767 (along with miR‑4707‑5p), LOC100129973 prevents miR‑4767 from repressing its target genes, Apoptosis Inhibitor 5 (API5) and BCL2 like 12 (BCL2L12), thereby allowing increased expression of these apoptosis repressors and ultimately reducing serum and fibroblast growth factor‑2 starvation‑induced apoptosis in vascular endothelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Discussions of diabetic kidney disease (DKD) have highlighted the roles of other microRNAs—such as miR‑4756—in promoting pathogenic processes (e.g., renal tubular epithelial cell epithelial-to-mesenchymal transition and endoplasmic reticulum stress via suppression of Sestrin2), suggesting that microRNAs can profoundly influence disease progression through distinct molecular targets and signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Similarly, investigations into colorectal cancer (CRC) have underscored the critical regulatory functions of long non‑coding RNAs like LINC00858, which modulate cancer progression via yet‐to‑be fully elucidated mechanisms. Although MIR4767 has not been implicated in CRC, the emerging theme across these studies is that non‑coding RNAs—including both microRNAs and lncRNAs—play diverse roles in cellular processes and disease, with miR‑4767 specifically contributing to the fine‑tuning of apoptotic responses in the vascular system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Lu, Shu Ya Huang, Le Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep21620"}], "href": "https://doi.org/10.1038/srep21620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26887505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26887505"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yijie Jia, Zongji Zheng, Yanlin Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4756 promotes albumin-induced renal tubular epithelial cell epithelial-to-mesenchymal transition and endoplasmic reticulum stress via targeting Sestrin2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27107"}], "href": "https://doi.org/10.1002/jcp.27107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30145827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30145827"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Zhan, Xin Liao, Zhongsheng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00858 promotes colorectal cancer by sponging miR-4766-5p to regulate PAK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-019-09506-3"}], "href": "https://doi.org/10.1007/s10565-019-09506-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31902050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31902050"}]}]}]}