{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNAs (miRNAs) have been recognized as pivotal regulators in cancer, influencing tumor initiation, progression, metastasis, and clinical outcomes. In the context of laryngeal cancer, the investigated miRNAs, including MIR4768-3p, appear to modulate key clinicopathologic features. Notably, the expression of MIR4768-3p was found to be inversely associated with lymph node metastasis, suggesting a potential tumor‐suppressive role in limiting cancer spread."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe study demonstrated that while other miRNAs, such as miR-29a-3p and miR-548aa, positively correlated with tumor stage and metastasis, reduced levels of MIR4768-3p were linked with lower metastatic potential. This negative correlation indicates that decreased expression of MIR4768-3p may help in restricting lymphatic dissemination of cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, the exposure to cigarette smoke was shown to modify the miRNA expression profile in laryngeal cancer patients. In smokers, MIR4768-3p, along with miR-548aa and miR-3713, exhibited a marked downregulation compared to nonsmokers, reinforcing the idea that environmental factors can influence miRNA-mediated modulation of tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Antoni Bruzgielewicz, Ewa Osuch-Wojcikiewicz, Kazimierz Niemczyk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients' Smoking Status."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2016.3464"}], "href": "https://doi.org/10.1089/dna.2016.3464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28430523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28430523"}]}]}]}