MIR4773-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 4773-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch into the mechanisms underlying osteoporosis has revealed that the regulation of the bone‐fat switch in bone marrow–derived mesenchymal stem cells (BMSCs) is critical for maintaining skeletal integrity. In a study (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", the gene EEF1B2 was shown to increase in expression during osteogenic differentiation while decreasing during adipogenic differentiation, thereby promoting osteogenesis and inhibiting adipogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Moreover, experimental suppression of EEF1B2 was observed to hinder osteogenic differentiation and mineralization and to simultaneously enhance adipogenic differentiation. Conversely, overexpression of EEF1B2 resulted in accelerated osteogenesis and reduced marrow adiposity, with evidence suggesting that these effects are mediated at least in part through the regulation of β-catenin activity during the differentiation process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "It is important to note that while the original inquiry focused on the function of MIR4773-1, the provided abstract does not mention or characterize MIR4773-1. Instead, the study emphasizes the role of EEF1B2 as a regulator of the bone–fat balance. The promising outcomes from manipulating EEF1B2 suggest its potential as a therapeutic target for metabolic bone diseases, though any direct involvement of MIR4773-1 in these processes remains to be elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuhao Feng, Zihang Feng, Yiran Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-024-05297-x"}], "href": "https://doi.org/10.1007/s00018-024-05297-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38878096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38878096"}]}]}]}
NCBI Gene ID 100616392
API
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Predicted Functions View MIR4773-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4773-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4773-1's ARCHS4 Predicted Functions.

Functional Associations

MIR4773-1 has 182 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for MIR4773-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4773-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4773-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4773-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4773-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4773-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4773-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4773-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4773-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.