{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the original query mentioned MIR4773-2, none of the provided abstracts describe any function for this microRNA. Instead, the literature focuses on the kinesin family member KIF18A and its multifaceted roles in cell division and genomic stability. For example, a study of mutant mice demonstrated that a conservative missense mutation (R308K) in the motor domain of KIF18A leads to severe germ cell depletion and infertility due to mitotic arrest and apoptosis—highlighting a unique, heightened sensitivity of germ cells to chromosome mis‐alignment during mitosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther work has identified KIF18A as a crucial promoter of tumorigenesis, particularly in colitis-associated colon cancer. KIF18A overexpression correlates with enhanced activation of the PI3K–Akt signaling pathway, promoting tumor cell proliferation and survival, whereas its loss not only protects mice from chemically induced colon cancer but also leads to increased cell apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies have further refined our understanding of KIF18A’s role in maintaining genomic integrity. In mouse models and cultured cells, KIF18A deficiency results in the formation of micronuclei; however, these micronuclei tend to develop stable nuclear envelopes, thereby limiting their potential to drive tumorigenesis unless combined with other genetic deficiencies such as loss of p53. Beyond its role in mitosis and chromosomal stability, initial findings also hint at a possible involvement of KIF18A in regulating host immunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anne Czechanski, Haein Kim, Candice Byers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kif18a is specifically required for mitotic progression during germ line development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2015.03.011"}], "href": "https://doi.org/10.1016/j.ydbio.2015.03.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25824710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25824710"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Houbao Zhu, Wangyang Xu, Hongxin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.07.032"}], "href": "https://doi.org/10.1016/j.bbrc.2013.07.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23872115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23872115"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Leslie A Sepaniac, Whitney Martin, Louise A Dionne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202101165"}], "href": "https://doi.org/10.1083/jcb.202101165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34515734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34515734"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Seyoung Kim, Yong-Bin Cho, Chi-Une Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Genomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13258-019-00875-x"}], "href": "https://doi.org/10.1007/s13258-019-00875-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31677127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31677127"}]}]}]}